Phenotypes associated with this allele

• Allele Symbol: Sh2d1b1^tm1.1Cpt
• Allele Name: targeted mutation 1.1, Cox Terhorst
• Allele ID: MGI:4840390
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sh2d1b1^tm1.1Cpt/Sh2d1b1^tm1.1Cpt	involves: BALB/cJ * C57BL/6	MGI:4840403

Genotype
MGI:4840403

hm1

• Allelic Composition: Sh2d1b1^tm1.1Cpt/Sh2d1b1^tm1.1Cpt
• Genetic Background: involves: BALB/cJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

impaired natural killer cell mediated cytotoxicity ( J:166054 )

• in vivo clearance of RMAS/CD48+ tumors cells is impaired compared to in wild-type mice

• NK cell P815/CD48+ tumors cell killing is abolished in vivo compared with wild-type cells

• NK cells are defective in anti-CD244 dependent killing of 51Cr-labeled P815 cells compared with wild-type mice

• however, NK cells efficiently kill YB2/0, YAC-1, and CHO cells

hematopoietic system

impaired natural killer cell mediated cytotoxicity ( J:166054 )

• in vivo clearance of RMAS/CD48+ tumors cells is impaired compared to in wild-type mice

• NK cell P815/CD48+ tumors cell killing is abolished in vivo compared with wild-type cells

• NK cells are defective in anti-CD244 dependent killing of 51Cr-labeled P815 cells compared with wild-type mice

• however, NK cells efficiently kill YB2/0, YAC-1, and CHO cells