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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sema4gtm1Kik
targeted mutation 1, Hitoshi Kikutani
MGI:4840318
Summary 8 genotypes


Genotype
MGI:4881695
hm1
Allelic
Composition		 Sema4gtm1Kik/Sema4gtm1Kik
Genetic
Background		 B6.Cg-Sema4gtm1Kik
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sema4gtm1Kik mutation (0 available); any Sema4g mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:167973 )
• mice exhibit no overt phenotype including normal cerebellum

renal/urinary system
renal/urinary system phenotype ( J:221423 )
N
• mice show normal kidney morphology and a normal response to kidney ischemia/reperfusion injury




Genotype
MGI:4881698
cx2
Allelic
Composition		 Plxnb2tm1Matl/Plxnb2+
Sema4gtm1Kik/Sema4gtm1Kik
Genetic
Background		 B6.Cg-Plxnb2tm1Matl Sema4gtm1Kik
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plxnb2tm1Matl mutation (2 available); any Plxnb2 mutation (87 available)
Sema4gtm1Kik mutation (0 available); any Sema4g mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:167973 )
N
• cerebellum morphology is normal




Genotype
MGI:4881699
cx3
Allelic
Composition		 Plxnb2tm1Matl/Plxnb2tm1Matl
Sema4gtm1Kik/Sema4gtm1Kik
Genetic
Background		 B6.Cg-Plxnb2tm1Matl Sema4gtm1Kik
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plxnb2tm1Matl mutation (2 available); any Plxnb2 mutation (87 available)
Sema4gtm1Kik mutation (0 available); any Sema4g mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal cerebellar granule cell migration ( J:167973 )
• in a transwell assay with stromal cell line-derived factor-1alpha (SDF-1alpha) or brain derived neurotrophic factor (BDNF), granule cell precursors exhibit impaired migration compared with wild-type cells and cells from Sema4gtm1Kik homozygotes

cellular
abnormal cerebellar granule cell migration ( J:167973 )
• in a transwell assay with stromal cell line-derived factor-1alpha (SDF-1alpha) or brain derived neurotrophic factor (BDNF), granule cell precursors exhibit impaired migration compared with wild-type cells and cells from Sema4gtm1Kik homozygotes




Genotype
MGI:5807148
cx4
Allelic
Composition		 Sema4bGt(RST235)Byg/Sema4bGt(RST235)Byg
Sema4dtm1Kik/Sema4dtm1Kik
Sema4gtm1Kik/Sema4gtm1Kik
Genetic
Background		 B6.Cg-Sema4bGt(RST235)Byg Sema4dtm1Kik Sema4gtm1Kik
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sema4bGt(RST235)Byg mutation (1 available); any Sema4b mutation (298 available)
Sema4dtm1Kik mutation (2 available); any Sema4d mutation (87 available)
Sema4gtm1Kik mutation (0 available); any Sema4g mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased susceptibility to kidney reperfusion injury ( J:221423 )
• following renal ischemia/reperfusion injury, mice exhibit misorganized, multi-layered tubular kidney epithelium compared to controls
• tubular defects after kidney injury are confined to the outer renal medulla

renal/urinary system
increased susceptibility to kidney reperfusion injury ( J:221423 )
• following renal ischemia/reperfusion injury, mice exhibit misorganized, multi-layered tubular kidney epithelium compared to controls
• tubular defects after kidney injury are confined to the outer renal medulla
abnormal renal tubule epithelium morphology ( J:221423 )
• following renal ischemia/reperfusion injury, mice exhibit misorganized, multi-layered tubular kidney epithelium compared to controls
• however, mice are viable and show no overt defects in kidney histology under normal conditions




Genotype
MGI:4881701
cx5
Allelic
Composition		 Sema4ctm1Matl/Sema4ctm1Matl
Sema4gtm1Kik/Sema4g+
Genetic
Background		 B6.Cg-Sema4ctm1Matl Sema4gtm1Kik
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sema4ctm1Matl mutation (0 available); any Sema4c mutation (36 available)
Sema4gtm1Kik mutation (0 available); any Sema4g mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal cerebellar granule layer morphology ( J:167973 )
• 60% of mice exhibit gaps in the granule layer of lobule II and X unlike wild-type mice
ectopic cerebellar granule cells ( J:167973 )
• 80% of mice exhibit ectopic granule cells in the molecular layer at subpilial positions unlike wild-type mice
abnormal cerebellum lobule morphology ( J:167973 )
• all mice exhibit rostral lobules VIII and IX fusion unlike in wild-type mice




Genotype
MGI:4881702
cx6
Allelic
Composition		 Sema4ctm1Matl/Sema4c+
Sema4gtm1Kik/Sema4gtm1Kik
Genetic
Background		 B6.Cg-Sema4ctm1Matl Sema4gtm1Kik
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sema4ctm1Matl mutation (0 available); any Sema4c mutation (36 available)
Sema4gtm1Kik mutation (0 available); any Sema4g mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal cerebellar granule layer morphology ( J:167973 )
• 50% of mice exhibit gaps in the granule layer of lobule II unlike wild-type mice
ectopic cerebellar granule cells ( J:167973 )
• 60% of mice exhibit ectopic granule cells in the molecular layer at subpilial positions unlike wild-type mice
abnormal cerebellum lobule morphology ( J:167973 )
• 69% of mice exhibit rostral lobules VIII and IX fusion unlike in wild-type mice




Genotype
MGI:4881703
cx7
Allelic
Composition		 Sema4ctm1Matl/Sema4ctm1Matl
Sema4gtm1Kik/Sema4gtm1Kik
Genetic
Background		 B6.Cg-Sema4ctm1Matl Sema4gtm1Kik
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sema4ctm1Matl mutation (0 available); any Sema4c mutation (36 available)
Sema4gtm1Kik mutation (0 available); any Sema4g mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal cerebellar granule layer morphology ( J:167973 )
• 67% of mice exhibit gaps in the granule layer of lobule II unlike wild-type mice
• 75% of mice exhibit gaps in the granule layer of lobule X unlike wild-type mice
ectopic cerebellar granule cells ( J:167973 )
• all mice exhibit ectopic granule cells in the molecular layer at subpilial positions unlike wild-type mice
abnormal cerebellum lobule morphology ( J:167973 )
• all mice exhibit rostral lobules VIII and IX fusion unlike in wild-type mice




Genotype
MGI:4881700
cx8
Allelic
Composition		 Sema4ctm1Matl/Sema4c+
Sema4gtm1Kik/Sema4g+
Genetic
Background		 B6.Cg-Sema4ctm1Matl Sema4gtm1Kik
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sema4ctm1Matl mutation (0 available); any Sema4c mutation (36 available)
Sema4gtm1Kik mutation (0 available); any Sema4g mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal cerebellar granule layer morphology ( J:167973 )
• 40% of mice exhibit gaps in the granule layer of lobule II unlike wild-type mice
ectopic cerebellar granule cells ( J:167973 )
• 40% of mice exhibit ectopic granule cells in the molecular layer at subpilial positions unlike wild-type mice
abnormal cerebellum lobule morphology ( J:167973 )
• 69% of mice exhibit rostral lobules VIII and IX fusion unlike in wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory