All Phenotypes Sema4c<tm1Matl> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sema4c^tm1Matl
targeted mutation 1, Marc Tessier-Lavigne
MGI:4840317

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sema4c^tm1Matl/Sema4c^tm1Matl	B6.129P2-Sema4c^tm1Matl	MGI:4881693
ht2	Sema4c^tm1Matl/Sema4c⁺	B6.129P2-Sema4c^tm1Matl	MGI:4881694
cx3	Plxnb2^tm1Matl/Plxnb2^tm1Matl Sema4c^tm1Matl/Sema4c^tm1Matl	B6.129P2-Sema4c^tm1Matl Plxnb2^tm1Matl	MGI:4881696
cx4	Plxnb2^tm1Matl/Plxnb2⁺ Sema4c^tm1Matl/Sema4c^tm1Matl	B6.129P2-Sema4c^tm1Matl Plxnb2^tm1Matl	MGI:4881697
cx5	Sema4c^tm1Matl/Sema4c⁺ Sema4g^tm1Kik/Sema4g⁺	B6.Cg-Sema4c^tm1Matl Sema4g^tm1Kik	MGI:4881700
cx6	Sema4c^tm1Matl/Sema4c^tm1Matl Sema4g^tm1Kik/Sema4g⁺	B6.Cg-Sema4c^tm1Matl Sema4g^tm1Kik	MGI:4881701
cx7	Sema4c^tm1Matl/Sema4c⁺ Sema4g^tm1Kik/Sema4g^tm1Kik	B6.Cg-Sema4c^tm1Matl Sema4g^tm1Kik	MGI:4881702
cx8	Sema4c^tm1Matl/Sema4c^tm1Matl Sema4g^tm1Kik/Sema4g^tm1Kik	B6.Cg-Sema4c^tm1Matl Sema4g^tm1Kik	MGI:4881703

Allelic Composition	Sema4c^tm1Matl/Sema4c^tm1Matl
Genetic Background	B6.129P2-Sema4c^tm1Matl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sema4c^tm1Matl mutation (0 available); any Sema4c mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:167973 )

• mice with exencephaly die shortly after first

nervous system

abnormal cerebellar granule cell migration ( J:167973 )

• migration of granule cell precursors (GCPs) out of an explant is reduced compared to in wild-type explants

• however, GCP migration in a transwell assay with stromal cell line-derived factor-1alpha (SDF-1alpha) or brain derived neurotrophic factor (BDNF) is normal

abnormal cerebellar granule layer morphology ( J:167973 )

• 50% of mice exhibit gaps in the granule layer of lobule II unlike wild-type mice

ectopic cerebellar granule cells ( J:167973 )

• 60% of mice exhibit ectopic granule cells in the molecular layer at subpilial positions unlike wild-type mice

abnormal cerebellum lobule morphology ( J:167973 )

• 80% of mice exhibit rostral lobules VIII and IX fusion with disruption of the basal lamina at the site of fusion unlike in wild-type mice

exencephaly ( J:167973 )

• in one third of mice

pigmentation

belly spot ( J:167973 )

• white patches along the ventral midline

integument

belly spot ( J:167973 )

• white patches along the ventral midline

cellular

abnormal cerebellar granule cell migration ( J:167973 )

• migration of granule cell precursors (GCPs) out of an explant is reduced compared to in wild-type explants

• however, GCP migration in a transwell assay with stromal cell line-derived factor-1alpha (SDF-1alpha) or brain derived neurotrophic factor (BDNF) is normal

renal/urinary system

renal/urinary system phenotype ( J:221423 )

N	• mice show normal kidney morphology and a normal response to kidney ischemia/reperfusion injury

Allelic Composition	Sema4c^tm1Matl/Sema4c⁺
Genetic Background	B6.129P2-Sema4c^tm1Matl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sema4c^tm1Matl mutation (0 available); any Sema4c mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cerebellar granule layer morphology ( J:167973 )

• 20% of mice exhibit gaps in the granule layer of lobule II unlike wild-type mice

ectopic cerebellar granule cells ( J:167973 )

• 10% of mice exhibit ectopic granule cells in the molecular layer at subpilial positions unlike wild-type mice

abnormal cerebellum lobule morphology ( J:167973 )

• 27% of mice exhibit rostral lobules VIII and IX fusion unlike in wild-type mice

Allelic Composition	Plxnb2^tm1Matl/Plxnb2^tm1Matl Sema4c^tm1Matl/Sema4c^tm1Matl
Genetic Background	B6.129P2-Sema4c^tm1Matl Plxnb2^tm1Matl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plxnb2^tm1Matl mutation (2 available); any Plxnb2 mutation (87 available)
Sema4c^tm1Matl mutation (0 available); any Sema4c mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cerebellar granule cell migration ( J:167973 )

• in a transwell assay with stromal cell line-derived factor-1alpha (SDF-1alpha) or brain derived neurotrophic factor (BDNF), granule cell precursors exhibit impaired migration compared with wild-type cells and cells form Sema4c^tm1Matl homozygotes

abnormal cerebellar granule layer morphology ( J:167973 )

• the internal granule layer of lobules II and III is disrupted compared to in wild-type mice and more severely disrupted compared to in Sema4c^tm1Matl homozygotes

cellular

abnormal cerebellar granule cell migration ( J:167973 )

Allelic Composition	Plxnb2^tm1Matl/Plxnb2⁺ Sema4c^tm1Matl/Sema4c^tm1Matl
Genetic Background	B6.129P2-Sema4c^tm1Matl Plxnb2^tm1Matl

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cerebellar granule layer morphology ( J:167973 )

• mice exhibit a gap in the lobule X unlike wild-type mice and Sema4c^tm1Matl homozygotes

Allelic Composition	Sema4c^tm1Matl/Sema4c⁺ Sema4g^tm1Kik/Sema4g⁺
Genetic Background	B6.Cg-Sema4c^tm1Matl Sema4g^tm1Kik

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sema4c^tm1Matl mutation (0 available); any Sema4c mutation (36 available)
Sema4g^tm1Kik mutation (0 available); any Sema4g mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cerebellar granule layer morphology ( J:167973 )

• 40% of mice exhibit gaps in the granule layer of lobule II unlike wild-type mice

ectopic cerebellar granule cells ( J:167973 )

• 40% of mice exhibit ectopic granule cells in the molecular layer at subpilial positions unlike wild-type mice

abnormal cerebellum lobule morphology ( J:167973 )

• 69% of mice exhibit rostral lobules VIII and IX fusion unlike in wild-type mice

Allelic Composition	Sema4c^tm1Matl/Sema4c^tm1Matl Sema4g^tm1Kik/Sema4g⁺
Genetic Background	B6.Cg-Sema4c^tm1Matl Sema4g^tm1Kik

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cerebellar granule layer morphology ( J:167973 )

• 60% of mice exhibit gaps in the granule layer of lobule II and X unlike wild-type mice

ectopic cerebellar granule cells ( J:167973 )

• 80% of mice exhibit ectopic granule cells in the molecular layer at subpilial positions unlike wild-type mice

abnormal cerebellum lobule morphology ( J:167973 )

• all mice exhibit rostral lobules VIII and IX fusion unlike in wild-type mice

Allelic Composition	Sema4c^tm1Matl/Sema4c⁺ Sema4g^tm1Kik/Sema4g^tm1Kik
Genetic Background	B6.Cg-Sema4c^tm1Matl Sema4g^tm1Kik

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cerebellar granule layer morphology ( J:167973 )

• 50% of mice exhibit gaps in the granule layer of lobule II unlike wild-type mice

ectopic cerebellar granule cells ( J:167973 )

• 60% of mice exhibit ectopic granule cells in the molecular layer at subpilial positions unlike wild-type mice

abnormal cerebellum lobule morphology ( J:167973 )

• 69% of mice exhibit rostral lobules VIII and IX fusion unlike in wild-type mice

Allelic Composition	Sema4c^tm1Matl/Sema4c^tm1Matl Sema4g^tm1Kik/Sema4g^tm1Kik
Genetic Background	B6.Cg-Sema4c^tm1Matl Sema4g^tm1Kik

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cerebellar granule layer morphology ( J:167973 )

• 67% of mice exhibit gaps in the granule layer of lobule II unlike wild-type mice

• 75% of mice exhibit gaps in the granule layer of lobule X unlike wild-type mice

ectopic cerebellar granule cells ( J:167973 )

• all mice exhibit ectopic granule cells in the molecular layer at subpilial positions unlike wild-type mice

abnormal cerebellum lobule morphology ( J:167973 )

• all mice exhibit rostral lobules VIII and IX fusion unlike in wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/14/2024 MGI 6.23