Phenotypes associated with this allele

• Allele Symbol: Ctsh^tm1Thre
• Allele Name: targeted mutation 1, Thomas Reinheckel
• Allele ID: MGI:4840055
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ctsh^tm1Thre/Ctsh^tm1Thre	B6N.129P2-Ctsh^tm1Thre	MGI:4840057
hm2	Ctsh^tm1Thre/Ctsh^tm1Thre	involves: 129P2/OlaHsd	MGI:5552740
cx3	Ctsc^tm1Ley/Ctsc^tm1Ley Ctsh^tm1Thre/Ctsh^tm1Thre	involves: 129P2/OlaHsd * 129X1/SvJ	MGI:4840058

Genotype
MGI:4840057

hm1

• Allelic Composition: Ctsh^tm1Thre/Ctsh^tm1Thre
• Genetic Background: B6N.129P2-Ctsh^tm1Thre

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

respiratory system

abnormal respiratory system physiology ( J:178096 )

• bronchoalveolar fluid exhibits impaired surface tension compared with wild-type mice

decreased surfactant secretion ( J:178096 )

• mice exhibit reduced surfactant B protein in the bronchoalveolar lavage compared with wild-type mice

reproductive system

reproductive system phenotype ( J:178096 )

N • mice exhibit normal reproduction

growth/size/body

growth/size/body region phenotype ( J:178096 )

N • normal growth

Genotype
MGI:5552740

hm2

• Allelic Composition: Ctsh^tm1Thre/Ctsh^tm1Thre
• Genetic Background: involves: 129P2/OlaHsd

vision/eye

abnormal eye morphology ( J:206689 )

• mice exhibit an abnormal eye globe, having an abnormal posterior chamber suggestive of an elongated axial length of the globe rather than the rounded appearance in wild-type

Genotype
MGI:4840058

cx3

• Allelic Composition: Ctsc^tm1Ley/Ctsc^tm1Ley; Ctsh^tm1Thre/Ctsh^tm1Thre
• Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

normal phenotype

no abnormal phenotype detected ( J:165930 )

• mice exhibit normal development, fertility, and lifespan