Phenotypes associated with this allele

• Allele Symbol: Myh4^arl
• Allele Name: ariel
• Allele ID: MGI:4839531
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Myh4^arl/Myh4^arl	involves: C3H/HeH * C57BL/6J	MGI:5314781

Genotype
MGI:5314781

hm1

• Allelic Composition: Myh4^arl/Myh4^arl
• Genetic Background: involves: C3H/HeH * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

myositis ( J:181892 )

• in degenerating muscles

• perivascular and perimysial inflammation

• largely affects fast muscles

abnormal skeletal muscle fiber morphology ( J:181892 )

• thick filaments fail to form

• accumulation of protein aggregates at P10 that grow rapidly

• pale and dark pink fibers in degenerating muscles

increased variability of skeletal muscle fiber size ( J:181892 )

• in degenerating muscles

centrally nucleated skeletal muscle fibers ( J:181892 )

• occasionally in degenerating muscles

skeletal muscle fiber degeneration ( J:181892 )

• myofibrillar and myofibre denegeration

muscular atrophy ( J:181892 )

• in muscles from the hind and forelimb, vertebra and hip

• largely affects fast muscles

behavior/neurological

abnormal gait ( J:181892 )

• rigid gait with elevated pelvis from P11

hindlimb paralysis ( J:181892 )

• by P13

immune system

myositis ( J:181892 )

• in degenerating muscles

• perivascular and perimysial inflammation

• largely affects fast muscles