Analysis Tools
immune system
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• ovalbumin-treated mice exhibit defective trafficking of pulmonary dendritic cells compared with similarly treated wild-type mice
• trafficking of antigen-loaded lung dendritic cells to mediastinal lymph nodes is impaired compared to in wild-type mice
• however, dendritic cells exhibit normal migration in vitro, in skin-painting experiments, and to lymph nodes of in vitro generated carboxyfluorescein succinimidyl ester-labeled dendritic cells
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• in a model of airway hypersensitivity, ovalbumin-treated mice exhibit lower bronchoalveolar lavage fluid levels of Th2 cytokines (IL4 and IL5) compared with similarly treated wild-type mice
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• mediastinal lymph nodes in ovalbumin-treated mice exhibit a 2-fold reduction in cellularity and reduced total dendritic cells compared to in similarly treated wild-type mice
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• in a model of airway hypersensitivity, ovalbumin-treated mice exhibit reduced leukocytes, eosinophil, and lymphocytes/mononuclear cells accumulation and lower bronchoalveolar lavage fluid levels of Th2 cytokines (IL4 and IL5) compared with similarly treated wild-type mice
• however, mice exhibit normal mucus production and airway resistance in response to methacholine
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• in dendritic cells of ovalbumin-challenged mice re-exposed to ovalbumin
• however, levels are normal in bronchoalveolar lavage fluid of ovalbumin-exposed mice
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• in the bronchoalveolar lavage fluid of ovalbumin-treated mice
• however, dendritic cells of ovalbumin-challenged mice re-exposed to ovalbumin is normal
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• in the bronchoalveolar lavage fluid of ovalbumin-treated mice
• from dendritic cells of ovalbumin-challenged mice re-exposed to ovalbumin
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cellular
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• ovalbumin-treated mice exhibit defective trafficking of pulmonary dendritic cells compared with similarly treated wild-type mice
• trafficking of antigen-loaded lung dendritic cells to mediastinal lymph nodes is impaired compared to in wild-type mice
• however, dendritic cells exhibit normal migration in vitro, in skin-painting experiments, and to lymph nodes of in vitro generated carboxyfluorescein succinimidyl ester-labeled dendritic cells
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hematopoietic system
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• ovalbumin-treated mice exhibit defective trafficking of pulmonary dendritic cells compared with similarly treated wild-type mice
• trafficking of antigen-loaded lung dendritic cells to mediastinal lymph nodes is impaired compared to in wild-type mice
• however, dendritic cells exhibit normal migration in vitro, in skin-painting experiments, and to lymph nodes of in vitro generated carboxyfluorescein succinimidyl ester-labeled dendritic cells
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• in a model of airway hypersensitivity, ovalbumin-treated mice exhibit lower bronchoalveolar lavage fluid levels of Th2 cytokines (IL4 and IL5) compared with similarly treated wild-type mice
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