Phenotypes associated with this allele

• Allele Symbol: Kdm6b^tm1Aki
• Allele Name: targeted mutation 1, Shizuo Akira
• Allele ID: MGI:4838334
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kdm6b^tm1Aki/Kdm6b^tm1Aki	involves: 129X1/SvJ * C57BL/6	MGI:4838336

Genotype
MGI:4838336

hm1

• Allelic Composition: Kdm6b^tm1Aki/Kdm6b^tm1Aki
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality ( J:164690 )

respiratory system

abnormal lung morphology ( J:164690 )

• almost no air space is observed in the lung unlike in wild-type mice

thick pulmonary interalveolar septum ( J:164690 )

immune system

impaired eosinophil recruitment ( J:164690 )

• when fetal livers cells are used in bone marrow chimeric mice, intraperitoneal recruitment of eosinophils induced by chitin is impaired compared to in similarly treated wild-type mice

• when fetal livers cells are used in bone marrow chimeric mice, lung recruitment of eosinophils induced by Nippostrongylus brasiliensisis infection is impaired compared to in similarly treated wild-type mice

abnormal response to infection ( J:164690 )

• when fetal livers cells are used in bone marrow chimeric mice, lung recruitment of eosinophils induced by Nippostrongylus brasiliensisis infection is impaired and fewer IL4 and IFN-gamma producing T cells compared to in similarly treated wild-type mice

hematopoietic system

impaired eosinophil recruitment ( J:164690 )

• when fetal livers cells are used in bone marrow chimeric mice, intraperitoneal recruitment of eosinophils induced by chitin is impaired compared to in similarly treated wild-type mice

• when fetal livers cells are used in bone marrow chimeric mice, lung recruitment of eosinophils induced by Nippostrongylus brasiliensisis infection is impaired compared to in similarly treated wild-type mice