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Allele Symbol Allele Name Allele ID |
Cdc20tm1Jvd targeted mutation 1, Jan M A van Deursen MGI:4838294 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• male mice exhibit normal reproduction and normal levels of apoptosis in the testes
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• female mice produce more aneuploid oocytes than wild-type mice
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• primary and secondary spermatocytes are more prone to aneuploidy compared to in wild-type mice
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• average time from metaphase entry to anaphase is twice as long as in wild-type oocytes
• chromosomes are misaligned during meiosis I in oocyte compared to in wild-type mice
• however, timing of germinal vesicle breakdown is normal
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• 4 of 7 female mice fail to produce pups
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• female mice produce an average 4-fold fewer litters with an average 15-fold lower number of pups compared with wild-type mice
• however, mice exhibit normal oogenesis and fertilization
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• female mice produce more aneuploid oocytes than wild-type mice
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• primary and secondary spermatocytes are more prone to aneuploidy compared to in wild-type mice
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• female mice produce more aneuploid oocytes than wild-type mice
• primary and secondary spermatocytes are more prone to aneuploidy compared to in wild-type mice
|
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• average time from metaphase entry to anaphase is twice as long as in wild-type oocytes
• chromosomes are misaligned during meiosis I in oocyte compared to in wild-type mice
• however, timing of germinal vesicle breakdown is normal
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• only 15% of embryos derived from dams form blastocysts compared with 93% of embryos collected from wild-type dams
• dams produce embryos that cease proliferating after the first cell division of preimplantation period and do not develop beyond the 4-cell stage unlike embryos from wild-type dams
• dams produce more aneuploid embryos compared with wild-type mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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