Phenotypes associated with this allele

• Allele Symbol: Wnt4^tm1.2Boer
• Allele Name: targeted mutation 1.2, Derek Boerboom
• Allele ID: MGI:4838181
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Wnt4^tm1.2Boer/Wnt4^tm1.2Boer	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ	MGI:4838183
cn2	Amhr2^tm3(cre)Bhr/Amhr2^+ Wnt4^tm1.1Boer/Wnt4^tm1.2Boer	involves: 129S1/Sv * 129S4/SvJae * 129S7/SvEvBrd * 129X1/SvJ	MGI:4838185

Genotype
MGI:4838183

hm1

• Allelic Composition: Wnt4^tm1.2Boer/Wnt4^tm1.2Boer
• Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:162337 )

• homozygous mice were found to die within 48 h after birth

renal/urinary system

abnormal kidney development ( J:162337 )

• severe developmental anomalies of the kidneys, reproductive tract, and gonads that were essentially identical to those previously described in Wnt4^tm1Amc null mice

reproductive system

abnormal reproductive system development ( J:162337 )

• severe developmental anomalies of the kidneys, reproductive tract, and gonads that were essentially identical to those previously described in Wnt4^tm1Amc null mice

Genotype
MGI:4838185

cn2

• Allelic Composition: Amhr2^tm3(cre)Bhr/Amhr2⁺; Wnt4^tm1.1Boer/Wnt4^tm1.2Boer
• Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129S7/SvEvBrd * 129X1/SvJ

mortality/aging

premature death ( J:162337 )

• severe ovarian phenotypes were always accompanied by variable degrees of growth retardation, poor body condition, a disheveled appearance, and frequently premature death

endocrine/exocrine glands

decreased mature ovarian follicle number ( J:162337 )

♀ • ovaries developed far fewer preovulatory and ovulatory follicles in response to gonadotropin treatment than control ovaries and often appeared to have fewer large secondary follicles as well

abnormal ovary development ( J:162337 )

♀ • ovaries developed far fewer preovulatory and ovulatory follicles in response to gonadotropin treatment than control ovaries and often appeared to have fewer large secondary follicles as well

♀ • fewer healthy antral follicles in 42-d-old mutant female

♀ • small subset of mutant female had very small ovaries that were devoid of antral follicles and corpora lutea at 8?12 wk of age

decreased ovary weight ( J:162337 )

♀ • only 49% the size of those of littermate controls

♀ • all stages of follicular development and corpora lutea could be identified in most adult

reproductive system

decreased mature ovarian follicle number ( J:162337 )

♀ • ovaries developed far fewer preovulatory and ovulatory follicles in response to gonadotropin treatment than control ovaries and often appeared to have fewer large secondary follicles as well

abnormal ovary development ( J:162337 )

♀ • ovaries developed far fewer preovulatory and ovulatory follicles in response to gonadotropin treatment than control ovaries and often appeared to have fewer large secondary follicles as well

♀ • fewer healthy antral follicles in 42-d-old mutant female

♀ • small subset of mutant female had very small ovaries that were devoid of antral follicles and corpora lutea at 8?12 wk of age

decreased ovary weight ( J:162337 )

♀ • only 49% the size of those of littermate controls

♀ • all stages of follicular development and corpora lutea could be identified in most adult

decreased litter size ( J:162337 )

• average litter size was only 54% that of the control group

growth/size/body

postnatal growth retardation ( J:162337 )

• severe ovarian phenotypes were always accompanied by variable degrees of growth retardation

renal/urinary system

decreased renal glomerulus number ( J:162337 )

abnormal kidney development ( J:162337 )

• severe developmental anomalies of the kidneys having few glomeruli

integument

disheveled coat ( J:162337 )

• severe ovarian phenotypes were always accompanied by a disheveled appearance