Analysis Tools|
Allele Symbol Allele Name Allele ID |
Wnt4tm1.1Boer targeted mutation 1.1, Derek Boerboom MGI:4838176 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• Female homozygous mice were found to have morphologically normal genitourinary tracts at birth, developed normally through adulthood, and demonstrated fertility indistinguishable from that of C57BL/6 wildtype mice.
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• severe ovarian phenotypes were always accompanied by variable degrees of growth retardation, poor body condition, a disheveled appearance, and frequently premature death
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• ovaries developed far fewer preovulatory and ovulatory follicles in response to gonadotropin treatment than control ovaries and often appeared to have fewer large secondary follicles as well
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• ovaries developed far fewer preovulatory and ovulatory follicles in response to gonadotropin treatment than control ovaries and often appeared to have fewer large secondary follicles as well
• fewer healthy antral follicles in 42-d-old mutant female
• small subset of mutant female had very small ovaries that were devoid of antral follicles and corpora lutea at 8?12 wk of age
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• only 49% the size of those of littermate controls
• all stages of follicular development and corpora lutea could be identified in most adult
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• ovaries developed far fewer preovulatory and ovulatory follicles in response to gonadotropin treatment than control ovaries and often appeared to have fewer large secondary follicles as well
|
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• ovaries developed far fewer preovulatory and ovulatory follicles in response to gonadotropin treatment than control ovaries and often appeared to have fewer large secondary follicles as well
• fewer healthy antral follicles in 42-d-old mutant female
• small subset of mutant female had very small ovaries that were devoid of antral follicles and corpora lutea at 8?12 wk of age
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• only 49% the size of those of littermate controls
• all stages of follicular development and corpora lutea could be identified in most adult
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• average litter size was only 54% that of the control group
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• severe ovarian phenotypes were always accompanied by variable degrees of growth retardation
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• severe developmental anomalies of the kidneys having few glomeruli
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• severe ovarian phenotypes were always accompanied by a disheveled appearance
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/30/2025 MGI 6.24 |
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