All Phenotypes App<tm2.1Zhe> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

App^tm2.1Zhe
targeted mutation 2.1, Hui Zheng
MGI:4838049

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	App^tm2.1Zhe/App^tm2.1Zhe	involves: 129S1/Sv * 129X1/SvJ	MGI:4838050
cx2	Aplp2^tm1Dbo/Aplp2^tm1Dbo App^tm2.1Zhe/App^tm2.1Zhe	involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ	MGI:4838051
cx3	Aplp2^tm1Dbo/Aplp2^tm1Dbo App^tm1.2Zhe/App^tm2.1Zhe	involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ	MGI:4838052

Allelic Composition	App^tm2.1Zhe/App^tm2.1Zhe
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
App^tm2.1Zhe mutation (0 available); any App mutation (89 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:165417 )

• normal growth and brain morphology

Allelic Composition	Aplp2^tm1Dbo/Aplp2^tm1Dbo App^tm2.1Zhe/App^tm2.1Zhe
Genetic Background	involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aplp2^tm1Dbo mutation (1 available); any Aplp2 mutation (30 available)
App^tm2.1Zhe mutation (0 available); any App mutation (89 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:165417 )

• most homozygotes die by 21 days of age

• born in normal numbers

nervous system

abnormal neuromuscular synapse morphology ( J:165417 )

• wider than in controls

Allelic Composition	Aplp2^tm1Dbo/Aplp2^tm1Dbo App^tm1.2Zhe/App^tm2.1Zhe
Genetic Background	involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aplp2^tm1Dbo mutation (1 available); any Aplp2 mutation (30 available)
App^tm1.2Zhe mutation (0 available); any App mutation (89 available)
App^tm2.1Zhe mutation (0 available); any App mutation (89 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:165417 )

• most homozygotes die by 21 days of age

• born in normal numbers

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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