Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rasgrp1m1Anu mutation
(2 available);
any
Rasgrp1 mutation
(55 available)
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immune system
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• CD44 is overexpressed on na=C3=AFve thymocytes and T cells in a T-cell-autonomous manner
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• subclinical autoimmune susceptibility
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hematopoietic system
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• CD44 is overexpressed on na=C3=AFve thymocytes and T cells in a T-cell-autonomous manner
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rasgrp1m1Anu mutation
(2 available);
any
Rasgrp1 mutation
(55 available)
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immune system
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N |
• mice exhibit normal frequency and number of mature CD4+ and CD8+ single positive thymocytes, regulatory T cell differentiation, positive selection and clonal deletion
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• accumulation of PD1+ Helios+ CD4+ T cells
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• activated or memory/effector CD4+ cells
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hematopoietic system
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• accumulation of PD1+ Helios+ CD4+ T cells
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• activated or memory/effector CD4+ cells
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Allelic
Composition |
Rasgrp1m1Anu/Rasgrp1+
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Genetic
Background |
involves: C57BL/6JSfdAnu * CBA/J |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rasgrp1m1Anu mutation
(2 available);
any
Rasgrp1 mutation
(55 available)
|
|
|
immune system
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N |
• suppressed accumulation of PD1+ Helios+ CD4+ T cells compared with Rasgrp1m1Anu homozygotes
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hematopoietic system
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N |
• hematopoietic cells transferred into bone marrow chimeras exhibit normal frequency of animals with antinuclear autoantibodies compared with chimeras receiving Rasgrp1m1Anu cells
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immune system
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N |
• profoundly suppressed accumulation of PD1+ Helios+ CD4+ T cells compared with Rasgrp1m1Anu homozygotes
• restored number of effector/memory and regulatory CD4+ T cells compared with Rasgrp1m1Anu homozygotes
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Analysis Tools