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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tlr8/Tlr7tm1Vlcg
targeted mutation 1, Velocigene
MGI:4837833
Summary 2 genotypes


Genotype
MGI:4837538
hm1
Allelic
Composition		 Tlr8/Tlr7tm1Vlcg/Tlr8/Tlr7tm1Vlcg
Genetic
Background		 B6.Cg-Tlr8/Tlr7tm1Vlcg Tlr8tm1Vlcg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr8/Tlr7tm1Vlcg mutation (0 available); any Tlr7 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system

hematopoietic system




Genotype
MGI:4837539
cx2
Allelic
Composition		 Tlr8/Tlr7tm1Vlcg/Tlr7+
Tlr8/Tlr7tm1Vlcg/Tlr8tm1Vlcg
Genetic
Background		 B6.Cg-Tlr8/Tlr7tm1Vlcg Tlr8tm1Vlcg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr8/Tlr7tm1Vlcg mutation (0 available); any Tlr8 mutation (11 available)
Tlr8/Tlr7tm1Vlcg mutation (0 available); any Tlr7 mutation (21 available)
Tlr8tm1Vlcg mutation (0 available); any Tlr8 mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal spleen marginal zone morphology ( J:165267 )
• mice exhibit an intermediate marginal zone phenotype compared with Tlr8tm1Vlcg and double homozygotes
decreased marginal zone B cell number ( J:165267 )
• 2 times lower than in double homozygotes
increased marginal zone B cell number ( J:165267 )
• 2 times higher than in Tlr8tm1Vlcg homozygotes
decreased IgG level ( J:165267 )
• compared with Tlr8tm1Vlcg homozygotes
increased IgG level ( J:165267 )
• compared with double homozygotes
decreased IgM level ( J:165267 )
• compared with Tlr8tm1Vlcg homozygotes
increased IgM level ( J:165267 )
• compared with double homozygotes
decreased anti-insulin autoantibody level ( J:165267 )
• compared with Tlr8tm1Vlcg homozygotes

hematopoietic system
abnormal spleen marginal zone morphology ( J:165267 )
• mice exhibit an intermediate marginal zone phenotype compared with Tlr8tm1Vlcg and double homozygotes
decreased marginal zone B cell number ( J:165267 )
• 2 times lower than in double homozygotes
increased marginal zone B cell number ( J:165267 )
• 2 times higher than in Tlr8tm1Vlcg homozygotes
decreased IgG level ( J:165267 )
• compared with Tlr8tm1Vlcg homozygotes
increased IgG level ( J:165267 )
• compared with double homozygotes
decreased IgM level ( J:165267 )
• compared with Tlr8tm1Vlcg homozygotes
increased IgM level ( J:165267 )
• compared with double homozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory