Phenotypes associated with this allele

• Allele Symbol: Tg(tetO-NOS2,-lacZ)240iMhus
• Allele Name: transgene insertion 240i, Mansoor Husain
• Allele ID: MGI:4837700
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(Myh6-tTA)6Smbf/0 Tg(tetO-NOS2,-lacZ)240iMhus/0	involves: C57BL/6 * CBA	MGI:4837726
tg2	Tg(tetO-NOS2,-lacZ)240iMhus/Tg(tetO-NOS2,-lacZ)240iMhus	C57BL/6-Tg(tetO-NOS2,-lacZ)240iMhus	MGI:4837725

Genotype
MGI:4837726

cx1

• Allelic Composition: Tg(Myh6-tTA)6Smbf/0; Tg(tetO-NOS2,-lacZ)240iMhus/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:132082 )

• following withdrawal of doxycycline

cardiovascular system

abnormal atrioventricular node morphology ( J:132082 )

• after doxycycline withdrawal, mice exhibit a trend towards increased inflammation in the atrioventricular node unlike wild-type mice

• however, there is no evidence of fibrosis, calcification, or necrosis

cardiac muscle necrosis ( J:132082 )

• mild following withdrawal of doxycycline

enlarged heart ( J:132082 )

• at 15 to 30 weeks after doxycycline withdrawal, mice with congestive heart failure exhibit increase chamber sizes compared with wild-type mice

increased heart weight ( J:132082 )

• following withdrawal of doxycycline

abnormal heart left ventricle morphology ( J:132082 )

• 30 days following the withdrawal of doxycycline, mice exhibit increased left ventricular end-diastolic dimension compared with wild-type mice

increased heart ventricle size ( J:132082 )

• following withdrawal of doxycycline

dilated heart ventricle ( J:132082 )

• following withdrawal of doxycycline

cardiac interstitial fibrosis ( J:132082 )

• at 15 to 30 weeks after doxycycline withdrawal in mice with congestive heart failure

abnormal cardiovascular system physiology ( J:132082 )

• at 15 to 30 weeks after doxycycline withdrawal, mice with congestive heart failure exhibit depressed hemodynamics compared with wild-type mice

ventricular tachycardia ( J:132082 )

• infrequently after doxycycline withdrawal

absent heartbeat ( J:132082 )

• after doxycycline withdrawal, mice exhibit sudden cardiac death associated with cardiac asystole preceded by a short burst of 2:1 block unlike wild-type mice

abnormal P wave ( J:132082 )

• after doxycycline withdrawal, mice exhibit bifid P waves with elongation of P-wave duration unlike wild-type mice

heart block ( J:132082 )

• progressive after doxycycline withdrawal

atrioventricular block ( J:132082 )

• after doxycycline withdrawal, 4 mice exhibit atrioventricular block with Wenckebach periodicity (i.e. progressive elongation of PR interval followed by dropped ventricular beats) unlike wild-type mice

prolonged PR interval ( J:132082 )

• after doxycycline withdrawal

prolonged P wave ( J:132082 )

• after doxycycline withdrawal

congestive heart failure ( J:132082 )

• in 6 of 78 mice 15 to 30 weeks after doxycycline withdrawal

heart inflammation ( J:132082 )

• mild following withdrawal of doxycycline

growth/size/body

enlarged heart ( J:132082 )

• at 15 to 30 weeks after doxycycline withdrawal, mice with congestive heart failure exhibit increase chamber sizes compared with wild-type mice

increased heart weight ( J:132082 )

• following withdrawal of doxycycline

increased body weight ( J:132082 )

• at 15 to 30 weeks after doxycycline withdrawal in mice with congestive heart failure

homeostasis/metabolism

edema ( J:132082 )

• at 15 to 30 weeks after doxycycline withdrawal in mice with congestive heart failure

immune system

heart inflammation ( J:132082 )

• mild following withdrawal of doxycycline

behavior/neurological

lethargy ( J:132082 )

• at 15 to 30 weeks after doxycycline withdrawal in mice with congestive heart failure

respiratory system

respiratory distress ( J:132082 )

• at 15 to 30 weeks after doxycycline withdrawal in mice with congestive heart failure

muscle

abnormal atrioventricular node morphology ( J:132082 )

• after doxycycline withdrawal, mice exhibit a trend towards increased inflammation in the atrioventricular node unlike wild-type mice

• however, there is no evidence of fibrosis, calcification, or necrosis

cardiac muscle necrosis ( J:132082 )

• mild following withdrawal of doxycycline

cellular

cardiac muscle necrosis ( J:132082 )

• mild following withdrawal of doxycycline

cardiac interstitial fibrosis ( J:132082 )

• at 15 to 30 weeks after doxycycline withdrawal in mice with congestive heart failure

Genotype
MGI:4837725

tg2

• Allelic Composition: Tg(tetO-NOS2,-lacZ)240iMhus/Tg(tetO-NOS2,-lacZ)240iMhus
• Genetic Background: C57BL/6-Tg(tetO-NOS2,-lacZ)240iMhus

normal phenotype

no abnormal phenotype detected ( J:132082 )