All Phenotypes Irs1<smla> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Irs1^smla
small phenotype
MGI:4837622

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Irs1^smla/Irs1^smla	involves: 129S1/SvImJ * 129S2/SvPas * C57BL/6	MGI:4837630
hm2	Irs1^smla/Irs1^smla	involves: 129S2/SvPas * C57BL/6J	MGI:4837629
cx3	Irs1^smla/Irs1^smla Serpinb2^tm2Dgi/Serpinb2^tm2Dgi	involves: 129S2/SvPas * C57BL/6J * DBA/2J	MGI:4837626

Allelic Composition	Irs1^smla/Irs1^smla
Genetic Background	involves: 129S1/SvImJ * 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irs1^smla mutation (1 available); any Irs1 mutation (55 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:164568 )

N	• Background Sensitivity: postnatal survival is normal unlike mice backcrossed to C57BL/6J

Allelic Composition	Irs1^smla/Irs1^smla
Genetic Background	involves: 129S2/SvPas * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irs1^smla mutation (1 available); any Irs1 mutation (55 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:164568 )

• mice exhibit decreased long term survival

postnatal lethality ( J:164568 )

• Background Sensitivity: mice further backcrossed to C57BL/6J (N3-N4) exhibit less than 2% survival at 2 weeks of age unlike mice backcrossed to 129S1/SvImJ

growth/size/body

decreased body size ( J:164568 )

Allelic Composition	Irs1^smla/Irs1^smla Serpinb2^tm2Dgi/Serpinb2^tm2Dgi
Genetic Background	involves: 129S2/SvPas * C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irs1^smla mutation (1 available); any Irs1 mutation (55 available)
Serpinb2^tm2Dgi mutation (0 available); any Serpinb2 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:164568 )

• mice begin to die shortly after weaning

postnatal lethality ( J:164568 )

• mice exhibit a trend towards reduced numbers at weaning

growth/size/body

decreased birth body size ( J:164568 )

decreased body size ( J:52283 , J:164568 )

• at birth, at 2 weeks, and in adult mice (J:164568)

decreased body weight ( J:164568 )

decreased body height ( J:164568 )

• mice exhibit proportional decrease in stature unlike wild-type mice

muscle

muscular atrophy ( J:164568 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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