Phenotypes associated with this allele

• Allele Symbol: Hspa4^tm1.1Miv
• Allele Name: targeted mutation 1.1, Nahid F Mivechi
• Allele ID: MGI:4836945
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hspa4^tm1.1Miv/Hspa4^tm1.1Miv	involves: BALB/cJ * C57BL/6	MGI:4836977
cx2	Hspa4^tm1.1Miv/Hspa4^tm1.1Miv Tg(APPSWE)2576Kha/0	involves: BALB/cJ * C57BL/6 * SJL	MGI:4836978

Genotype
MGI:4836977

hm1

• Allelic Composition: Hspa4^tm1.1Miv/Hspa4^tm1.1Miv
• Genetic Background: involves: BALB/cJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:164904 )

N • mice exhibit cued fear conditioning, Y-maze performance, and open field behaviors

impaired contextual conditioning behavior ( J:164904 )

abnormal motor capabilities/coordination/movement ( J:164904 )

• at 18 months, mice exhibit a deficiency in their ability to grasp a bar compared with wild-type mice

limb grasping ( J:164904 )

• in 10% to 15% of mice at 18 months

nervous system

tau protein deposits ( J:164904 )

• age-dependent

neurofibrillary tangles ( J:164904 )

• age-dependent

Genotype
MGI:4836978

cx2

• Allelic Composition: Hspa4^tm1.1Miv/Hspa4^tm1.1Miv; Tg(APPSWE)2576Kha/0
• Genetic Background: involves: BALB/cJ * C57BL/6 * SJL

mortality/aging

premature death ( J:164904 )

• many mice die before 7 months of age

nervous system

neurofibrillary tangles ( J:164904 )

• at 6 months, mice develop neurofibril tangles unlike Tg(APPSWE)2576Kha mice

• at 7 months, mice develop senility plaques unlike Tg(APPSWE)2576Kha mice

neurodegeneration ( J:164904 )

• neuron degeneration is more severe than in Tg(APPSWE)2576Kha mice