About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nlrp3m3Btlr
mutation 3, Bruce Beutler
MGI:4835554
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ot1
 		Nlrp3m3Btlr/? C57BL/6J-Nlrp3m3Btlr MGI:4835563


Genotype
MGI:4835563
ot1
Allelic
Composition		 Nlrp3m3Btlr/?
Genetic
Background		 C57BL/6J-Nlrp3m3Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrp3m3Btlr mutation (0 available); any Nlrp3 mutation (61 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal interleukin-1 beta secretion ( J:164866 )
• peritoneal macrophages from mice with this mutation exhibit a reduced interleukin-beta response to lipopolysaccharide, a toll-like receptor 4 (TLR4) ligand, plus nigericin (NALP3 Inflammasome Screen)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory