Phenotypes associated with this allele

• Allele Symbol: Mdm2^tm4.1Glo
• Allele Name: targeted mutation 4.1, Guillermina Lozano
• Allele ID: MGI:4835495
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mdm2^tm4.1Glo/Mdm2^tm4.1Glo	B6.129S6-Mdm2^tm4.1Glo	MGI:4835497
cx2	Mdm2^tm4.1Glo/Mdm2^tm4.1Glo Trp53^tm3.1Glo/Trp53^+	B6.129S-Mdm2^tm4.1Glo Trp53^tm3.1Glo	MGI:4835500

Genotype
MGI:4835497

hm1

• Allelic Composition: Mdm2^tm4.1Glo/Mdm2^tm4.1Glo
• Genetic Background: B6.129S6-Mdm2^tm4.1Glo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

cellular phenotype ( J:164201 )

N • MEFs display increase proliferation relative to mice homozygous for Mdm2^tm3.1Glo

N • apoptosis is increased in the thymus following a low dose of IR radiation compared to mice homozygous for Mdm2^tm3.1Glo

neoplasm

increased sarcoma incidence ( J:164201 )

• soft tissue sarcoma in 1 of 5 mice

Genotype
MGI:4835500

cx2

• Allelic Composition: Mdm2^tm4.1Glo/Mdm2^tm4.1Glo; Trp53^tm3.1Glo/Trp53⁺
• Genetic Background: B6.129S-Mdm2^tm4.1Glo Trp53^tm3.1Glo

neoplasm

increased lymphoma incidence ( J:164201 )

• in 1 mouse

increased histiocytic sarcoma incidence ( J:164201 )

increased carcinoma incidence ( J:164201 )

• an undefined carcinoma is reported in 1 mouse

increased adenocarcinoma incidence ( J:164201 )

• undefined adenocarcinomas are reported

increased liver adenocarcinoma incidence ( J:164201 )

increased squamous cell carcinoma incidence ( J:164201 )

• in 1 mouse

increased sarcoma incidence ( J:164201 )

• soft tissue sarcoma

increased fibrosarcoma incidence ( J:164201 )

increased osteosarcoma incidence ( J:164201 )

skeleton

increased osteosarcoma incidence ( J:164201 )

liver/biliary system

increased liver adenocarcinoma incidence ( J:164201 )