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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cd44tm2.1Ugu
targeted mutation 2.1, Ursula Gunthert
MGI:4835490
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cd44tm2.1Ugu/Cd44tm2.1Ugu B6.129-Cd44tm2.1Ugu MGI:4843550


Genotype
MGI:4843550
hm1
Allelic
Composition		 Cd44tm2.1Ugu/Cd44tm2.1Ugu
Genetic
Background		 B6.129-Cd44tm2.1Ugu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd44tm2.1Ugu mutation (7 available); any Cd44 mutation (75 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased T cell proliferation ( J:199279 )
• of lymph node T cells repeatedly stimulated with MOG35-55
decreased susceptibility to experimental autoimmune encephalomyelitis ( J:199279 )
• with reduced symptoms, fewer inflammatory infiltrates and increased apoptotic activity

hematopoietic system
decreased T cell proliferation ( J:199279 )
• of lymph node T cells repeatedly stimulated with MOG35-55

cellular
decreased T cell proliferation ( J:199279 )
• of lymph node T cells repeatedly stimulated with MOG35-55




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory