All Phenotypes Fgfr2<hob> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Fgfr2^hob
hobbyhorse
MGI:4835423

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fgfr2^hob/Fgfr2^hob	involves: C57BL/6J	MGI:5614309
ht2	Fgfr2^tm1.1Dor/Fgfr2^hob	involves: 129X1/SvJ * C57BL/6J * FVB/N	MGI:5614321

Allelic Composition	Fgfr2^hob/Fgfr2^hob
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr2^hob mutation (0 available); any Fgfr2 mutation (88 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development ( J:216825 )

• viable until late in gestation

limbs/digits/tail

absent limbs ( J:216825 )

• embryos lack limbs

• however, a presumptive hindlimb bud is present up to approximately E12.5

reproductive system

primary sex reversal ( J:216825 )

• XY embryos exhibit complete gonadal sex reversal as evidenced by ovarian morphology and expression of ovarian markers and absence of Sertoli cell makers at E14.5

• entry of germ cells into meiosis is seen at E14.6, indicating germ cell sex-reversal

respiratory system

pulmonary hypoplasia ( J:216825 )

• hypoplastic lungs

Allelic Composition	Fgfr2^tm1.1Dor/Fgfr2^hob
Genetic Background	involves: 129X1/SvJ * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr2^hob mutation (0 available); any Fgfr2 mutation (88 available)
Fgfr2^tm1.1Dor mutation (0 available); any Fgfr2 mutation (88 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased fetal size ( J:216825 )

• slightly smaller than wild-type at E14.5