Phenotypes associated with this allele

• Allele Symbol: Plp1^tm1.1Gow
• Allele Name: targeted mutation 1.1, Alexander Gow
• Allele ID: MGI:4835263
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ot1	Plp1^tm1.1Gow/Y	Not Specified	MGI:4835336

Genotype
MGI:4835336

ot1

• Allelic Composition: Plp1^tm1.1Gow/Y
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal cerebellum morphology ( J:62287 )

♂

abnormal cerebellum white matter morphology ( J:62287 )

♂ • white matter subjacent to the internal granule layer and the molecular layers is disorganized

abnormal cerebellar granule layer morphology ( J:62287 )

♂ • some abnormalities observed

gliosis ( J:62287 )

♂ • diffuse

neurodegeneration ( J:62287 )

♂ • observed in white matter by electron microscopy

axon degeneration ( J:62287 )

♂ • redundant myelin sheaths

♂ • myelin vacuolization

axonal spheroids ( J:62287 )

♂ • filled with mitochondria and other organelles

abnormal myelination ( J:62287 )

♂ • myelin structure has a longer periodicity than for controls

♂ • initial myelinogenesis is normal

demyelination ( J:62287 )

♂ • widespread demyelination as mice age

behavior/neurological

impaired coordination ( J:62287 )

♂ • rotarod performance deteriorates as demyelination progresses

♂ • mice perform well on a rotarod until about 1 year of age after which performance declines