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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Pomc)#Low
transgene insertion, Malcolm J Low
MGI:4833830
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Pomctm1Low/Pomctm1Low
Tg(Pomc)#Low/0 		involves: 129 * C57BL/6 * CBA * DBA/2 * Swiss Webster MGI:4833835
cx2
 		Pomctm1Low/Pomc+
Tg(Pomc)#Low/0 		involves: 129 * C57BL/6 * CBA * DBA/2 * Swiss Webster MGI:4833836
cx3
 		Pomctm1Low/Pomctm1Low
Tg(Pomc)#Low/Tg(Pomc)#Low 		involves: 129 * C57BL/6 * CBA * DBA/2 * Swiss Webster MGI:4833837
tg4
 		Tg(Pomc)#Low/0 involves: C57BL/6 * DBA/2 MGI:4833838


Genotype
MGI:4833835
cx1
Allelic
Composition		 Pomctm1Low/Pomctm1Low
Tg(Pomc)#Low/0
Genetic
Background		 involves: 129 * C57BL/6 * CBA * DBA/2 * Swiss Webster
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pomctm1Low mutation (1 available); any Pomc mutation (23 available)
Tg(Pomc)#Low mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
increased pituitary adenoma incidence ( J:119240 )
• melanotroph adenomas

mortality/aging
mortality/aging ( J:119240 )
N
• mice exhibit normal survival perinatally

homeostasis/metabolism
abnormal corticosterone level ( J:119240 )
• male mice exhibit an abnormal corticosterone secretion pattern with exaggerated nadir and peak levels compared with wild-type mice
• however, corticosterone secretion pattern in female mice is normal
decreased adrenocorticotropin level ( J:119240 )
• in the hypothalamus
• however, expression is restored in the pituitary
decreased circulating adrenocorticotropin level ( J:119240 )
• in male and female mice under acute restrain stress

endocrine/exocrine glands
increased adrenal gland zona fasciculata size ( J:119240 )
• the zona fasciculata is hypertrophic with increased volume of eosinophilic cytoplasm per cell and decreased numbers of cells per high-power field compared to in wild-type mice
enlarged adrenal glands ( J:119240 )
• greater in male than female mice
increased pituitary adenoma incidence ( J:119240 )
• melanotroph adenomas

growth/size/body
increased body weight ( J:119240 )

neoplasm
increased pituitary adenoma incidence ( J:119240 )
• melanotroph adenomas




Genotype
MGI:4833836
cx2
Allelic
Composition		 Pomctm1Low/Pomc+
Tg(Pomc)#Low/0
Genetic
Background		 involves: 129 * C57BL/6 * CBA * DBA/2 * Swiss Webster
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pomctm1Low mutation (1 available); any Pomc mutation (23 available)
Tg(Pomc)#Low mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased pituitary adenoma incidence ( J:119240 )
• melanotroph adenomas

nervous system
increased pituitary adenoma incidence ( J:119240 )
• melanotroph adenomas

endocrine/exocrine glands
increased pituitary adenoma incidence ( J:119240 )
• melanotroph adenomas




Genotype
MGI:4833837
cx3
Allelic
Composition		 Pomctm1Low/Pomctm1Low
Tg(Pomc)#Low/Tg(Pomc)#Low
Genetic
Background		 involves: 129 * C57BL/6 * CBA * DBA/2 * Swiss Webster
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pomctm1Low mutation (1 available); any Pomc mutation (23 available)
Tg(Pomc)#Low mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
increased body weight ( J:119240 )
• compared with Tg(Pomc)#Low homozygotes

homeostasis/metabolism
increased circulating corticosterone level ( J:119240 )
• compared with Tg(Pomc)#Low homozygotes




Genotype
MGI:4833838
tg4
Allelic
Composition		 Tg(Pomc)#Low/0
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
endocrine/exocrine gland phenotype ( J:119240 )
N
• mice exhibit normal adrenal gland weight

growth/size/body
growth/size/body region phenotype ( J:119240 )
N
• mice exhibit normal body weight

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:119240 )
N
• mice exhibit normal basal corticosterone levels




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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory