Phenotypes associated with this allele

• Allele Symbol: Tg(Ins2-Sec61a1)#Gek
• Allele Name: transgene insertion, Nicholas Gekakis
• Allele ID: MGI:4831008
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Sec61a1^m1Gek/Sec61a1^m1Gek Tg(Ins2-Sec61a1)#Gek/0	C57BL/6-Sec61a1^m1Gek Tg(Ins2-Sec61a1)#Gek	MGI:4831013

Genotype
MGI:4831013

cx1

• Allelic Composition: Sec61a1^m1Gek/Sec61a1^m1Gek; Tg(Ins2-Sec61a1)#Gek/0
• Genetic Background: C57BL/6-Sec61a1^m1Gek Tg(Ins2-Sec61a1)#Gek

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:164159 )

N • mice fed a high fat diet exhibit normal glucose and insulin homeostasis

liver/biliary system

enlarged liver ( J:164159 )

• in mice fed a high fat diet that is not as severe as in similarly treated Sec61a1^m1Gek homozygotes

hepatic steatosis ( J:164159 )

• in mice fed a high fat diet

liver cirrhosis ( J:164159 )

• in older mice when fed a high fat diet

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:164159 )

N • mice fed a high fat diet exhibit normal beta cell survival

abnormal pancreatic beta cell morphology ( J:164159 )

• endoplasmic reticulum distension observed in single homozygotes is almost completely rescued

growth/size/body

decreased lean body mass ( J:164159 )

• in mice fed a high fat diet that is not as severe as in similarly treated Sec61a1^m1Gek homozygotes

decreased body size ( J:164159 )

• in mice fed a high fat diet that is not as severe as in similarly treated Sec61a1^m1Gek homozygotes

enlarged liver ( J:164159 )

• in mice fed a high fat diet that is not as severe as in similarly treated Sec61a1^m1Gek homozygotes

adipose tissue

decreased total body fat amount ( J:164159 )

• in mice fed a high fat diet that is not as severe as in similarly treated Sec61a1^m1Gek homozygotes