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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cubntm1Rkoz
targeted mutation 1, Renata Kozyraki
MGI:4831004
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cubntm1Rkoz/Cubntm1Rkoz
Meox2tm1(cre)Sor/Meox2+ 		involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 MGI:4831005
cn2
 		Cubntm1Rkoz/Cubntm1Rkoz
Lrp2tm1Tew/Lrp2tm1Tew
Meox2tm1(cre)Sor/Meox2+ 		involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 MGI:4831007


Genotype
MGI:4831005
cn1
Allelic
Composition		 Cubntm1Rkoz/Cubntm1Rkoz
Meox2tm1(cre)Sor/Meox2+
Genetic
Background		 involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cubntm1Rkoz mutation (0 available); any Cubn mutation (160 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:164025 )
• only 19% of the expected 25% of mice are observed indicating some lethality

homeostasis/metabolism
albuminuria ( J:164025 )
• selective daily albumin excretion is increased about 6-fold
abnormal vitamin B12 level ( J:164025 )
• plasma levels of vitamin B12 are severely decreased due to absence of uptake of intrinsic factor vitamin B12 complex in the ileum

renal/urinary system
albuminuria ( J:164025 )
• selective daily albumin excretion is increased about 6-fold
abnormal renal reabsorption ( J:164025 )
• mice exhibit a decrease in uptake of albumin and no uptake of intrinsic factor vitamin B12 complex by proximal tubule cells
• however, urinary tubular uptake or excretion of vitamin D-binding protein is not affected




Genotype
MGI:4831007
cn2
Allelic
Composition		 Cubntm1Rkoz/Cubntm1Rkoz
Lrp2tm1Tew/Lrp2tm1Tew
Meox2tm1(cre)Sor/Meox2+
Genetic
Background		 involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cubntm1Rkoz mutation (0 available); any Cubn mutation (160 available)
Lrp2tm1Tew mutation (0 available); any Lrp2 mutation (260 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, incomplete penetrance ( J:164025 )
• most die shortly after birth, however a few mice live to adulthood

homeostasis/metabolism
albuminuria ( J:164025 )
• mice exhibit albuminuria to the same extent as conditional homozygous Cubn mice

renal/urinary system
albuminuria ( J:164025 )
• mice exhibit albuminuria to the same extent as conditional homozygous Cubn mice
abnormal kidney morphology ( J:164025 )
• renal morphology is similar to that in single homozygous Lrp2 mice
abnormal renal reabsorption ( J:164025 )
• absence of uptake of apoA-I by proximal tubule cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory