Phenotypes associated with this allele

• Allele Symbol: Stat2^p117
• Allele Name: pedigree p117
• Allele ID: MGI:4830698
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Stat2^p117/Stat2^p117	C57BL/6J-Stat2^P117	MGI:4830775

Genotype
MGI:4830775

hm1

• Allelic Composition: Stat2^p117/Stat2^p117
• Genetic Background: C57BL/6J-Stat2^P117

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to Picornaviridae infection induced morbidity/mortality ( J:164049 )

• all mice die within 2-4 days after infection with 0.2 pfu of Encephalomyocarditis, while all wild-type mice survive

immune system

decreased dendritic cell number ( J:164049 )

• the percentages and numbers of cDC (CD11c+CD11b+) are greatly reduced in the spleen

decreased plasmacytoid dendritic cell number ( J:164049 )

• the percentages and numbers of pDC (CD11c+B220+) are greatly reduced in the spleen

decreased level of surface class I molecules ( J:164049 )

• cells stimulated with IFN alpha express low levels of MHC class I and ICAM-1 as compared with wildtype controls

abnormal level of surface class II molecules ( J:164049 )

• TLR ligand-induced MHC class II is lower on pDC than wild-type although basal levels are not different

• basal level of MHC class II expression is lower on cDC and its inducibility by TLR ligands is almost impaired

increased susceptibility to Picornaviridae infection induced morbidity/mortality ( J:164049 )

• all mice die within 2-4 days after infection with 0.2 pfu of Encephalomyocarditis, while all wild-type mice survive

hematopoietic system

decreased dendritic cell number ( J:164049 )

• the percentages and numbers of cDC (CD11c+CD11b+) are greatly reduced in the spleen

decreased plasmacytoid dendritic cell number ( J:164049 )

• the percentages and numbers of pDC (CD11c+B220+) are greatly reduced in the spleen