All Phenotypes Rr103<tm3Sia> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rr103^tm3Sia
targeted mutation 3, Shinichi Aizawa
MGI:4830691

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Rr103^tm3Sia/Rr103^tm3Sia Otx2^tm1Sia/Otx2⁺	involves: C57BL/6 * CBA	MGI:4830713
cx2	Emx1^tm1Sia/Emx1^tm1Sia Rr103^tm3Sia/Rr103^tm3Sia	involves: C57BL/6 * CBA	MGI:4830714

Allelic Composition	Rr103^tm3Sia/Rr103^tm3Sia Otx2^tm1Sia/Otx2⁺
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otx2^tm1Sia mutation (1 available); any Otx2 mutation (50 available)
Rr103^tm3Sia mutation (0 available); any Rr103 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

absent diencephalon ( J:163926 )

• at E8.5, mice exhibit a loss of diencephalic structures compared with wild-type mice

Allelic Composition	Emx1^tm1Sia/Emx1^tm1Sia Rr103^tm3Sia/Rr103^tm3Sia
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1^tm1Sia mutation (1 available); any Emx1 mutation (34 available)
Rr103^tm3Sia mutation (0 available); any Rr103 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal pallium development ( J:163926 )

• mice exhibit a moderate loss of the medial pallium compared with wild-type mice

absent dentate gyrus ( J:163926 )

small hippocampus ( J:163926 )

abnormal cerebral cortex morphology ( J:163926 )

• mice exhibit moderately defective cortical lamination compared with wild-type mice

• however, mice exhibit normal ganglionic eminences

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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