Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htr2ctm1.1Eme mutation
(0 available);
any
Htr2c mutation
(12 available)
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Allelic Composition |
Htr2ctm1.1Eme/Htr2c+
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Genetic Background |
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htr2ctm1.1Eme mutation
(0 available);
any
Htr2c mutation
(12 available)
|
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growth/size/body
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• not as severe as in homozygotes or hemizygotes
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• not as severe as in homozygotes or hemizygotes
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behavior/neurological
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• gastric milk content is decreased compared to in wild-type mice
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Allelic Composition |
Htr2ctm1.1Eme/Y
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Genetic Background |
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htr2ctm1.1Eme mutation
(0 available);
any
Htr2c mutation
(12 available)
|
|
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mortality/aging
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• Background Sensitivity: on a predominantly 129S6/SvEvTac background,10% to 20% of mice die between P21 and P24
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• Background Sensitivity: in a cross with a C57BL/6J male, 75% of mice die between P8 and P12 with none surviving beyond P15
• however, mortality can be minimized by feeding wet food paste on a predominantly 129S6/SvEvTac background
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behavior/neurological
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• gastric milk content is decreased compared to in wild-type mice
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• in adult mice when food consumption is corrected for weight
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• in weanlings (P2-P28) but not adults on a rotarod
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• in weanlings (P2-P28) but not adults
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growth/size/body
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• at P21 despite normal birth weight
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• mice fail to thrive after birth
• however, mice exhibit normal growth rate after weaning
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homeostasis/metabolism
muscle
pigmentation
integument