Phenotypes associated with this allele

• Allele Symbol: Dscam^2J
• Allele Name: 2 Jackson
• Allele ID: MGI:4830358
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dscam^2J/Dscam^2J	C3H/HeDiSn-Dscam^2J/GrsrJ	MGI:4830360
hm2	Dscam^2J/Dscam^2J	C3Sn.Cg-Pde6b^+ Dscam^2J/Rwb	MGI:4830776
hm3	Dscam^2J/Dscam^2J	involves: C3H/HeDiSnJ	MGI:5554392

Genotype
MGI:4830360

hm1

• Allelic Composition: Dscam^2J/Dscam^2J
• Genetic Background: C3H/HeDiSn-Dscam^2J/GrsrJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired balance ( J:163979 )

impaired swimming ( J:163979 )

• although the auditory brain stem response is normal, homozygotes do not swim in a straight line, and sink after failing to hold their noses above water

abnormal posture ( J:163979 )

• homozygotes have a severely arched back and walk on their toes

abnormal resting posture ( J:163979 )

• homozygotes differ from their littermates as early as 2 days of age in that they rest on their backs rather than their stomachs and they struggle to maintain balance

trunk curl ( J:163979 )

craniofacial

domed cranium ( J:163979 )

• in all homozygotes

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:163979 )

N • normal auditory brainstem response

skeleton

domed cranium ( J:163979 )

• in all homozygotes

kyphosis ( J:163979 )

• pronounced thoracic kyphosis

vision/eye

abnormal retina morphology ( J:163979 )

abnormal amacrine cell morphology ( J:163979 , J:179393 )

• the dopaminergic amacrine cells have fasciculated neurites and are organized into clumps instead of mosaics (J:163979)

• lamination defects in bNOS-positive and cholinergic amacrine cells (J:179393)

disorganized retina ganglion layer ( J:163979 )

disorganized retina inner nuclear layer ( J:163979 )

nervous system

abnormal axon fasciculation ( J:179393 )

• in bNOS-positive amacrine cells

abnormal amacrine cell morphology ( J:163979 , J:179393 )

• the dopaminergic amacrine cells have fasciculated neurites and are organized into clumps instead of mosaics (J:163979)

• lamination defects in bNOS-positive and cholinergic amacrine cells (J:179393)

cellular

abnormal axon fasciculation ( J:179393 )

• in bNOS-positive amacrine cells

Genotype
MGI:4830776

hm2

• Allelic Composition: Dscam^2J/Dscam^2J
• Genetic Background: C3Sn.Cg-Pde6b⁺ Dscam^2J/Rwb

nervous system

abnormal amacrine cell morphology ( J:163979 )

• the calbindin-positive amacrine cells lack organized lamination and the three distinct bands of these cells normally seen in the retinal inner plexiform layer are not found

vision/eye

abnormal amacrine cell morphology ( J:163979 )

• the calbindin-positive amacrine cells lack organized lamination and the three distinct bands of these cells normally seen in the retinal inner plexiform layer are not found

Genotype
MGI:5554392

hm3

• Allelic Composition: Dscam^2J/Dscam^2J
• Genetic Background: involves: C3H/HeDiSnJ

Retinal abnormalities in Dscam^3J/Dscam^3J and Dscam^2J/Dscam^2J mice

nervous system

abnormal retina cone bipolar cell morphology ( J:195831 )

• type 2 and type 6 cone bipolar cells have lamination specificity defects

vision/eye

abnormal retina morphology ( J:195831 )

• retina displays increased cell number, with ectopic cells in inner plexiform layer projecting into the inner nuclear layer

abnormal retina cone bipolar cell morphology ( J:195831 )

• type 2 and type 6 cone bipolar cells have lamination specificity defects

abnormal retina neuronal layer morphology ( J:195831 )

• retinal neuritis lamination is disorganized

abnormal retina ganglion layer morphology ( J:195831 )

• ganglion cell spacing and arborization are disrupted

abnormal retina inner nuclear layer morphology ( J:195831 )

• layer contains fascicles of cell processes unlike even lamination in control retinas

• amacrine cell spacing and arborization are disrupted