All Phenotypes Trim33<tm1.1Los> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tg(CAG-cre)13Miya/0 Trim33^tm1.1Los/Trim33^tm1.2Los	involves: 129 * 129S2/SvPas * C57BL/6 * SJL	MGI:4830330
cn2	Trim33^tm1.1Los/Trim33^tm1.2Los Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺	involves: 129S2/SvPas * C57BL/6 * CBA * SJL	MGI:4830326
cn3	Smad4^tm1Rdp/Smad4^tm1.1Rdp Trim33^tm1.1Los/Trim33^tm1.2Los Tg(CAG-cre)13Miya/0	involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * SJL	MGI:4830328

Allelic Composition	Tg(CAG-cre)13Miya/0 Trim33^tm1.1Los/Trim33^tm1.2Los
Genetic Background	involves: 129 * 129S2/SvPas * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-cre)13Miya mutation (1 available)
Trim33^tm1.1Los mutation (0 available); any Trim33 mutation (71 available)
Trim33^tm1.2Los mutation (0 available); any Trim33 mutation (71 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal embryo development ( J:163858 )

• stated to be indistinguishable from mice homozygous for Trim33^tm1.2Ros

abnormal anterior visceral endoderm morphology ( J:163858 )

• expanded at E5.5

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, incomplete penetrance ( J:163858 )

• few embryos survive to E10

embryo

embryo phenotype ( J:163858 )

N	• unlike in homozygous germline null mice, no defects are seen in the anterior visceral endoderm or the extraembryonic ectoderm

abnormal endoderm development ( J:163858 )

• expression analysis indicates an almost radial expansion of the definitive endoderm at E7.5

abnormal mesendoderm development ( J:163858 )

• duplications of anterior axial mesendoderm tissues

decreased embryo size ( J:163858 )

• seen in about 1/3 of embryos that also have a defect in primitive streak morphology

incomplete rostral neuropore closure ( J:163858 )

• at E10 the few surviving embryos display open neural folds

abnormal primitive node morphology ( J:163858 )

• expanded in surviving embryos at E8.0

• duplications of node tissues

abnormal primitive streak elongation ( J:163858 )

• about 1/3 of embryos lack an overtly elongated streak

nervous system

incomplete rostral neuropore closure ( J:163858 )

• at E10 the few surviving embryos display open neural folds

abnormal brain development ( J:163858 )

• at E10 the few surviving embryos display defective brain development

growth/size/body

decreased embryo size ( J:163858 )

• seen in about 1/3 of embryos that also have a defect in primitive streak morphology

Allelic Composition	Smad4^tm1Rdp/Smad4^tm1.1Rdp Trim33^tm1.1Los/Trim33^tm1.2Los Tg(CAG-cre)13Miya/0
Genetic Background	involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad4^tm1.1Rdp mutation (0 available); any Smad4 mutation (43 available)
Smad4^tm1Rdp mutation (0 available); any Smad4 mutation (43 available)
Tg(CAG-cre)13Miya mutation (1 available)
Trim33^tm1.1Los mutation (0 available); any Trim33 mutation (71 available)
Trim33^tm1.2Los mutation (0 available); any Trim33 mutation (71 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal embryo development ( J:163858 )

• identical to mice null for Smad4 alone

absent anterior visceral endoderm ( J:163858 )

• not induced at E5.5

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