Analysis Tools|
Allele Symbol Allele Name Allele ID |
Kcnq1ot1tm1.1Ckan targeted mutation 1.1, Chandrasekhar Kanduri MGI:4830272 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice are normal and fertile
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| N |
• methylation of the altered allele's promoter is normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• when this allele is inherited paternally, mice exhibit altered DNA methylation at somatically acquired differentially methylated regions compared with wild-type mice
• however, histone modifications to ubiquitously imprinted genes is normal
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• when this allele is inherited paternally, mice exhibit lineage-specific relaxes imprinting of ubiquitously imprinted genes compared with wild-type mice
• however, genes imprinted only in the placenta are normal
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/30/2025 MGI 6.24 |
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