Phenotypes associated with this allele

• Allele Symbol: Kcnq1ot1^tm1.1Ckan
• Allele Name: targeted mutation 1.1, Chandrasekhar Kanduri
• Allele ID: MGI:4830272
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kcnq1ot1^tm1.1Ckan/Kcnq1ot1^tm1.1Ckan	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:4830273
ht2	Kcnq1ot1^tm1.1Ckan/Kcnq1ot1^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * M. spretus	MGI:4830275

Genotype
MGI:4830273

hm1

• Allelic Composition: Kcnq1ot1^tm1.1Ckan/Kcnq1ot1^tm1.1Ckan
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:163857 )

• mice are normal and fertile

cellular

cellular phenotype ( J:163857 )

N • methylation of the altered allele's promoter is normal

Genotype
MGI:4830275

ht2

• Allelic Composition: Kcnq1ot1^tm1.1Ckan/Kcnq1ot1⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * M. spretus

cellular

abnormal DNA methylation ( J:163857 )

• when this allele is inherited paternally, mice exhibit altered DNA methylation at somatically acquired differentially methylated regions compared with wild-type mice

• however, histone modifications to ubiquitously imprinted genes is normal

abnormal imprinting ( J:163857 )

• when this allele is inherited paternally, mice exhibit lineage-specific relaxes imprinting of ubiquitously imprinted genes compared with wild-type mice

• however, genes imprinted only in the placenta are normal