Phenotypes associated with this allele

• Allele Symbol: Ace^tm8.1Keb
• Allele Name: targeted mutation 8.1, Kenneth E Bernstein
• Allele ID: MGI:4830151
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ace^tm8.1Keb/Ace^tm8.1Keb	involves: 129 * C57BL/6	MGI:4830268
hm2	Ace^tm8.1Keb/Ace^tm8.1Keb	involves: 129 * C57BL/6 * FVB/N	MGI:4830255

Genotype
MGI:4830268

hm1

• Allelic Composition: Ace^tm8.1Keb/Ace^tm8.1Keb
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:163454 )

N • mice exhibit normal susceptibility to bleomycin-induced lung injury

decreased angiotensin I-converting enzyme activity ( J:163454 )

• activity of the N-terminus (measured by N-acetyl-seryl-aspartyl-lysyl-proline hydrolysis) is slightly decreased compared to in wild-type mice

Genotype
MGI:4830255

hm2

• Allelic Composition: Ace^tm8.1Keb/Ace^tm8.1Keb
• Genetic Background: involves: 129 * C57BL/6 * FVB/N

homeostasis/metabolism

decreased circulating angiotensin II level ( J:163902 )

• angiotensin II plasma levels are increased to a small degree compared to in wild-type mice

• the ratio of angiotensin II to angiotensin I plasma levels is decreased compared to in wild-type mice

abnormal circulating protein level ( J:163902 )

• angiotensin I plasma levels are increased greater than 7-fold compared to in wild-type mice

decreased urine osmolality ( J:163902 )

• under water deprivation conditions, mice exhibit a reduced increase in urine osmolality compared with similarly treated wild-type mice

abnormal angiotensin I-converting enzyme activity ( J:163902 )

• angiotensin I-converting enzyme (ACE) activity is independent of chloride concentration unlike in wild-type mice

decreased angiotensin I-converting enzyme activity ( J:163902 )

• ACE activity in the testis is reduced to 3% of the activity observed in wild-type

increased renin activity ( J:163902 )

• 2.6-fold

abnormal response/metabolism to endogenous compounds ( J:163902 )

• the increase in blood pressure induced by angiotensin I or angiotensin II infusion is reduced compared to in similarly treated wild-type mice

renal/urinary system

renal/urinary system phenotype ( J:163902 )

N • kidney morphology, including kidney vasculature, is normal

decreased urine osmolality ( J:163902 )

• under water deprivation conditions, mice exhibit a reduced increase in urine osmolality compared with similarly treated wild-type mice

cardiovascular system

cardiovascular system phenotype ( J:163902 )

N • mice exhibit normal systolic blood pressure, bradykinin reduction of blood pressure, hematocrit, and kidney vasculature

abnormal systemic arterial blood pressure ( J:163902 )

• the increase in blood pressure induced by angiotensin I or angiotensin II infusion is reduced compared to in similarly treated wild-type mice