Phenotypes associated with this allele

• Allele Symbol: Entpd5^tm1Rre
• Allele Name: targeted mutation 1, Robert Read
• Allele ID: MGI:4830114
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Entpd5^tm1Rre/Entpd5^tm1Rre	involves: 129S5/SvEvBrd * C57BL/6J	MGI:4830138

Genotype
MGI:4830138

hm1

• Allelic Composition: Entpd5^tm1Rre/Entpd5^tm1Rre
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:163795 )

• grows more slowly and are still stunted at 1 year of age

enlarged liver ( J:163795 )

• at 45 to 62 weeks of age showed a more eccentric lobular orientation

homeostasis/metabolism

increased circulating bilirubin level ( J:163795 )

hypoglycemia ( J:163795 )

increased circulating alanine transaminase level ( J:163795 )

increased circulating alkaline phosphatase level ( J:163795 )

decreased circulating serum albumin level ( J:163795 )

decreased cholesterol level ( J:163795 )

• significantly increased proliferation of hepatocytes in both young and older mice

decreased triglyceride level ( J:163795 )

reproductive system

abnormal sperm flagellum morphology ( J:163795 )

♂ • decreased numbers of tail structures within tubular lumina and an absence of normal spermatozoa in the epididymis

male infertility ( J:163795 )

♂

liver/biliary system

abnormal Kupffer cell morphology ( J:163795 )

• bile staining of Kupffer cells

increased hepatocyte apoptosis ( J:163795 )

• in older mice,45-62 weeks old, degenerating hepatocytes are greatly enlarged, pale, and rounded

increased hepatocyte proliferation ( J:163795 )

enlarged liver ( J:163795 )

• at 45 to 62 weeks of age showed a more eccentric lobular orientation

liver inflammation ( J:163795 )

• occasional periportal infiltrates of lymphocytes with smaller numbers of histiocytes and granulocytes

abnormal hepatocyte morphology ( J:163795 )

• diffuse, moderate to prominent, enlargement of centrilobular hepatocytes at 20 weeks of age

• an increased amounts of coarsely variegated cytoplasm with clumps and stripes of basophilic material juxtaposed with areas of pale vacuolated or typical eosinophilic cytoplasm

abnormal oval cell morphology ( J:163795 )

increased hepatocellular carcinoma incidence ( J:163795 )

increased liver adenoma incidence ( J:163795 )

abnormal oval cell physiology ( J:163795 )

• Oval cell proliferation is more prominent in older mice

immune system

abnormal Kupffer cell morphology ( J:163795 )

• bile staining of Kupffer cells

liver inflammation ( J:163795 )

• occasional periportal infiltrates of lymphocytes with smaller numbers of histiocytes and granulocytes

cardiovascular system

abnormal Kupffer cell morphology ( J:163795 )

• bile staining of Kupffer cells

hematopoietic system

abnormal Kupffer cell morphology ( J:163795 )

• bile staining of Kupffer cells

neoplasm

increased hepatocellular carcinoma incidence ( J:163795 )

increased liver adenoma incidence ( J:163795 )

cellular

abnormal sperm flagellum morphology ( J:163795 )

♂ • decreased numbers of tail structures within tubular lumina and an absence of normal spermatozoa in the epididymis

increased hepatocyte apoptosis ( J:163795 )

• in older mice,45-62 weeks old, degenerating hepatocytes are greatly enlarged, pale, and rounded

increased hepatocyte proliferation ( J:163795 )