Phenotypes associated with this allele

• Allele Symbol: Zfat^tm1Sawa
• Allele Name: targeted mutation 1, Senji Shirasawa
• Allele ID: MGI:4829941
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zfat^tm1Sawa/Zfat^tm1Sawa	B6.Cg-Zfat^tm1Sawa	MGI:4829943

Genotype
MGI:4829943

hm1

• Allelic Composition: Zfat^tm1Sawa/Zfat^tm1Sawa
• Genetic Background: B6.Cg-Zfat^tm1Sawa

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:163605 )

• midgestational lethality, no exact time of lethality provided

embryo

failure of initiation of embryo turning ( J:163605 )

• by E9.5

abnormal spongiotrophoblast layer morphology ( J:163605 )

• not well developed at E8.0

abnormal visceral yolk sac blood island morphology ( J:163605 )

• at E8 and E8.5 blood islands are spindle shaped

• at E8 the number of blood islands and the number of hematopoietic progenitor cells in the blood islands are decreased

pale yolk sac ( J:163605 )

• bloodless at E9.5

abnormal embryonic hematopoiesis ( J:163605 )

• decrease in the number of hematopoietic progenitor cells in the blood islands at E8.0

• decrease in the ratio of hematopoietic progenitor cells to endothelia cells in blood islands at E8

hematopoietic system

abnormal embryonic hematopoiesis ( J:163605 )

• decrease in the number of hematopoietic progenitor cells in the blood islands at E8.0

• decrease in the ratio of hematopoietic progenitor cells to endothelia cells in blood islands at E8