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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fndc3btm1Maim
targeted mutation 1, Masayoshi Imagawa
MGI:4822558
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fndc3btm1Maim/Fndc3btm1Maim B6.129S2-Fndc3btm1Maim MGI:4822564
hm2
 		Fndc3btm1Maim/Fndc3btm1Maim involves: 129S2/SvPas MGI:4822566


Genotype
MGI:4822564
hm1
Allelic
Composition		 Fndc3btm1Maim/Fndc3btm1Maim
Genetic
Background		 B6.129S2-Fndc3btm1Maim
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fndc3btm1Maim mutation (2 available); any Fndc3b mutation (151 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:163660 )
• all mice are dead by P1
• all mice delivered by caesarean section die within 15 minutes

cellular
abnormal cell adhesion ( J:163660 )
• mouse embryonic fibroblasts exhibit reduced cell adhesion and cell spreading with reduced stress fiber formation compared with wild-type cells
abnormal cell differentiation ( J:163660 )
• mouse embryonic fibroblasts exhibit reduced angiogenesis compared with wild-type cells
decreased fibroblast cell migration ( J:163660 )
• mouse embryonic fibroblasts in a wound healing assay exhibit reduced migration compared with wild-type cells
decreased fibroblast proliferation ( J:163660 )
• mouse embryonic fibroblasts

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:163660 )
N
• newborn mice exhibit normal energy homeostasis




Genotype
MGI:4822566
hm2
Allelic
Composition		 Fndc3btm1Maim/Fndc3btm1Maim
Genetic
Background		 involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fndc3btm1Maim mutation (2 available); any Fndc3b mutation (151 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell differentiation ( J:162425 )
• mouse embryonic fibroblasts (MEFs) transplanted into athymic mice develop into ossified tissues unlike similarly treated wild-type cells
• MEFs exhibit enhanced osteogenesis compared with wild-type cells
• MEFs exhibit impaired adipogenesis compared with wild-type cells

skeleton
increased bone ossification ( J:162425 )
• mouse embryonic fibroblasts (MEFs) transplanted into athymic mice develop into ossified tissues unlike similarly treated wild-type cells
• MEFs exhibit enhanced osteogenesis compared with wild-type cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory