Analysis Tools
immune system
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• lymphocytes stimulated with S1P and FTY729-P exhibit continued cell migration compared with wild-type cells are refractory to continued chemotactic stimulation
• lymphocytes exhibit more pronounced migration in response to FTY720-P than S1P
• however, lymphocyte egress form lymph nodes is normal
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• modestly in the spleen but not in circulating blood, lymph nodes, or lung tissue
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• modestly in the spleen but not in circulating blood, lymph nodes, or lung tissue
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• TY720-treated mice exhibit a slower decrease in CD4+ and CD8+ cells with a quicker recovery compared with similarly treated wild-type mice
• the lymphopenia kinetics of AUY954-treated mice are delayed, attenuated and recovered faster than in similarly treated wild-type mice
• 2-acetyl-4-tetrahydroxybutylimidazole (THI)-induced lymphopenia is decreased compared to in similarly treated wild-type mice
• lymphocytes fail to respond to FTY720 when transferred into wild-type mice unlike wild-type cells transferred into mutant mice
• however, endothelial cells used in adoptive transfer experiments do not influence FTY720-mediated lymphocyte egress rates
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homeostasis/metabolism
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• FTY720-treated mice exhibit a slower decrease in CD4+ and CD8+ cells with a quicker recovery compared with similarly treated wild-type mice
• the lymphopenia kinetics of AUY954-treated mice are delayed, attenuated and recovered faster than in similarly treated wild-type mice
• 2-acetyl-4-tetrahydroxybutylimidazole (THI)-induced lymphopenia is decreased compared to in similarly treated wild-type mice
• lymphocytes fail to respond to FTY720 when transferred into wild-type mice unlike wild-type cells transferred into mutant mice
• however, endothelial cells used in adoptive transfer experiments do not influence FTY720-mediated lymphocyte egress rates
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hematopoietic system
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• lymphocytes stimulated with S1P and FTY729-P exhibit continued cell migration compared with wild-type cells are refractory to continued chemotactic stimulation
• lymphocytes exhibit more pronounced migration in response to FTY720-P than S1P
• however, lymphocyte egress form lymph nodes is normal
|
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• modestly in the spleen but not in circulating blood, lymph nodes, or lung tissue
|
|
• modestly in the spleen but not in circulating blood, lymph nodes, or lung tissue
|
|
• TY720-treated mice exhibit a slower decrease in CD4+ and CD8+ cells with a quicker recovery compared with similarly treated wild-type mice
• the lymphopenia kinetics of AUY954-treated mice are delayed, attenuated and recovered faster than in similarly treated wild-type mice
• 2-acetyl-4-tetrahydroxybutylimidazole (THI)-induced lymphopenia is decreased compared to in similarly treated wild-type mice
• lymphocytes fail to respond to FTY720 when transferred into wild-type mice unlike wild-type cells transferred into mutant mice
• however, endothelial cells used in adoptive transfer experiments do not influence FTY720-mediated lymphocyte egress rates
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cellular
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• lymphocytes stimulated with S1P and FTY729-P exhibit continued cell migration compared with wild-type cells are refractory to continued chemotactic stimulation
• lymphocytes exhibit more pronounced migration in response to FTY720-P than S1P
• however, lymphocyte egress form lymph nodes is normal
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