Phenotypes associated with this allele

• Allele Symbol: Nfkbib^tm1Bal
• Allele Name: targeted mutation 1, David Baltimore
• Allele ID: MGI:4822433
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nfkbib^tm1Bal/Nfkbib^tm1Bal	B6.129S1-Nfkbib^tm1Bal	MGI:4822434

Genotype
MGI:4822434

hm1

• Allelic Composition: Nfkbib^tm1Bal/Nfkbib^tm1Bal
• Genetic Background: B6.129S1-Nfkbib^tm1Bal

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:163302 )

• in LPS-treated mice

immune system

decreased circulating interleukin-1 beta level ( J:163302 )

• in LPS-treated mice

decreased circulating interleukin-6 level ( J:163302 )

• in LPS-treated mice

decreased circulating tumor necrosis factor level ( J:163302 )

• LPS-treated mice exhibit a strong decrease in serum TNFalpha levels compared with similarly treated wild-type mice

• mice treated with collagen to induce arthritis exhibit decreased serum TNFalpha levels compared with similarly treated wild-type mice

decreased tumor necrosis factor secretion ( J:163302 )

• in thioglycollate-elicited peritoneal macrophages from LPS-treated mice

decreased susceptibility to induced arthritis ( J:163302 )

• mice treated with collagen to induce arthritis exhibit delayed onset, lower incidence, and decreased severity of arthritis with reduced swelling of joints, bone destruction, and serum TNF-alpha compared with similarly treated wild-type mice

decreased susceptibility to endotoxin shock ( J:163302 )

• with reduced mortality and circulating levels of IL6, IL1b, and TNF-alpha

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:163302 )

• in LPS-treated mice

homeostasis/metabolism

decreased circulating interleukin-1 beta level ( J:163302 )

• in LPS-treated mice

decreased circulating interleukin-6 level ( J:163302 )

• in LPS-treated mice

decreased circulating tumor necrosis factor level ( J:163302 )

• LPS-treated mice exhibit a strong decrease in serum TNFalpha levels compared with similarly treated wild-type mice

• mice treated with collagen to induce arthritis exhibit decreased serum TNFalpha levels compared with similarly treated wild-type mice

skeleton

decreased susceptibility to induced arthritis ( J:163302 )

• mice treated with collagen to induce arthritis exhibit delayed onset, lower incidence, and decreased severity of arthritis with reduced swelling of joints, bone destruction, and serum TNF-alpha compared with similarly treated wild-type mice