About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tbx2tm2.2Vmc
targeted mutation 2.2, Vincent M Christoffels
MGI:4822020
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tbx2tm2.2Vmc/Tbx2tm2.2Vmc involves: 129S4/SvJaeSor * 129S7/SvEvBrd * FVB MGI:4822024


Genotype
MGI:4822024
hm1
Allelic
Composition		 Tbx2tm2.2Vmc/Tbx2tm2.2Vmc
Genetic
Background		 involves: 129S4/SvJaeSor * 129S7/SvEvBrd * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx2tm2.2Vmc mutation (0 available); any Tbx2 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Tbx2tm2.2Vmc/Tbx2tm2.2Vmc embryo shows duplication of digit IV on both hindlimbs

mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:163063 )
• no viable embryos are obtained after E13.5

limbs/digits/tail
postaxial polydactyly ( J:163063 )
• have a duplication of digit IV of both hind limbs

cardiovascular system
abnormal fetal atrioventricular canal morphology ( J:163063 )
• abnormal left atrioventricular canal tissue




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory