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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tpi1a-m6Neu
mutation 6, Neuherberg
MGI:4821798
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tpi1a-m6Neu/Tpi1a-m6Neu involves: 101/El * C3H/El MGI:4821799
ht2
 		Tpi1a-m6Neu/Tpi1+ involves: 101/El * C3H/El MGI:4821800


Genotype
MGI:4821799
hm1
Allelic
Composition		 Tpi1a-m6Neu/Tpi1a-m6Neu
Genetic
Background		 involves: 101/El * C3H/El
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tpi1a-m6Neu mutation (1 available); any Tpi1 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased spleen weight ( J:163223 )
• spleen somatic index is increased compared to in wild-type mice
decreased spleen enzyme/coenzyme activity ( J:163223 )
• triosephosphate isomerase activity is reduced compared to in wild-type mice

homeostasis/metabolism
abnormal enzyme/coenzyme activity ( J:163223 )
• triosephosphate isomerase activity in the blood, lung, spleen, heart, liver, kidney, and brain is reduced compared to in wild-type mice
decreased heart enzyme/coenzyme activity ( J:163223 )
• triosephosphate isomerase activity is reduced compared to in wild-type mice
decreased spleen enzyme/coenzyme activity ( J:163223 )
• triosephosphate isomerase activity is reduced compared to in wild-type mice
decreased brain enzyme/coenzyme activity ( J:163223 )
• triosephosphate isomerase activity is reduced compared to in wild-type mice
decreased kidney enzyme/coenzyme activity ( J:163223 )
• triosephosphate isomerase activity is reduced compared to in wild-type mice
decreased liver enzyme/coenzyme activity ( J:163223 )
• triosephosphate isomerase activity is reduced compared to in wild-type mice
decreased lung enzyme/coenzyme activity ( J:163223 )
• triosephosphate isomerase activity is reduced compared to in wild-type mice

nervous system
decreased brain enzyme/coenzyme activity ( J:163223 )
• triosephosphate isomerase activity is reduced compared to in wild-type mice

renal/urinary system
decreased kidney enzyme/coenzyme activity ( J:163223 )
• triosephosphate isomerase activity is reduced compared to in wild-type mice

immune system
increased spleen weight ( J:163223 )
• spleen somatic index is increased compared to in wild-type mice

respiratory system
decreased lung enzyme/coenzyme activity ( J:163223 )
• triosephosphate isomerase activity is reduced compared to in wild-type mice

growth/size/body
increased spleen weight ( J:163223 )
• spleen somatic index is increased compared to in wild-type mice

cardiovascular system
decreased heart enzyme/coenzyme activity ( J:163223 )
• triosephosphate isomerase activity is reduced compared to in wild-type mice

liver/biliary system
decreased liver enzyme/coenzyme activity ( J:163223 )
• triosephosphate isomerase activity is reduced compared to in wild-type mice




Genotype
MGI:4821800
ht2
Allelic
Composition		 Tpi1a-m6Neu/Tpi1+
Genetic
Background		 involves: 101/El * C3H/El
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tpi1a-m6Neu mutation (1 available); any Tpi1 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal enzyme/coenzyme activity ( J:163223 )
• triosephosphate isomerase activity in the blood, lung, spleen, heart, liver, kidney, and brain is reduced compared to in wild-type mice
decreased heart enzyme/coenzyme activity ( J:163223 )
• triosephosphate isomerase activity is reduced compared to in wild-type mice
decreased spleen enzyme/coenzyme activity ( J:163223 )
• triosephosphate isomerase activity is reduced compared to in wild-type mice
decreased brain enzyme/coenzyme activity ( J:163223 )
• triosephosphate isomerase activity is reduced compared to in wild-type mice
decreased kidney enzyme/coenzyme activity ( J:163223 )
• triosephosphate isomerase activity is reduced compared to in wild-type mice
decreased liver enzyme/coenzyme activity ( J:163223 )
• triosephosphate isomerase activity is reduced compared to in wild-type mice
decreased lung enzyme/coenzyme activity ( J:163223 )
• triosephosphate isomerase activity is reduced compared to in wild-type mice

cardiovascular system
decreased heart enzyme/coenzyme activity ( J:163223 )
• triosephosphate isomerase activity is reduced compared to in wild-type mice

hematopoietic system
decreased spleen enzyme/coenzyme activity ( J:163223 )
• triosephosphate isomerase activity is reduced compared to in wild-type mice

liver/biliary system
decreased liver enzyme/coenzyme activity ( J:163223 )
• triosephosphate isomerase activity is reduced compared to in wild-type mice

nervous system
decreased brain enzyme/coenzyme activity ( J:163223 )
• triosephosphate isomerase activity is reduced compared to in wild-type mice

renal/urinary system
decreased kidney enzyme/coenzyme activity ( J:163223 )
• triosephosphate isomerase activity is reduced compared to in wild-type mice

respiratory system
decreased lung enzyme/coenzyme activity ( J:163223 )
• triosephosphate isomerase activity is reduced compared to in wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory