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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cacng7tm1.1Mwa
targeted mutation 1.1, Masahiko Watanabe
MGI:4821765
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cacng7tm1.1Mwa/Cacng7tm1.1Mwa involves: C57BL/6 * C57BL/6N * CBA MGI:4821784
cx2
 		Cacng2tm1.1Mwa/Cacng2tm1.1Mwa
Cacng7tm1.1Mwa/Cacng7tm1.1Mwa 		involves: C57BL/6 * C57BL/6N * CBA MGI:4821785


Genotype
MGI:4821784
hm1
Allelic
Composition		 Cacng7tm1.1Mwa/Cacng7tm1.1Mwa
Genetic
Background		 involves: C57BL/6 * C57BL/6N * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cacng7tm1.1Mwa mutation (0 available); any Cacng7 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:163029 )
• indistinguishable from wild-type controls




Genotype
MGI:4821785
cx2
Allelic
Composition		 Cacng2tm1.1Mwa/Cacng2tm1.1Mwa
Cacng7tm1.1Mwa/Cacng7tm1.1Mwa
Genetic
Background		 involves: C57BL/6 * C57BL/6N * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cacng2tm1.1Mwa mutation (0 available); any Cacng2 mutation (26 available)
Cacng7tm1.1Mwa mutation (0 available); any Cacng7 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:163029 )
• 70% of control mouse body weight

behavior/neurological
ataxia ( J:163029 )
• ataxic gait more severe than in Cacng2tm1Mwa single homozygotes
abnormal gait ( J:163029 )
• ataxic gait more severe than in Cacng2tm1Mwa single homozygotes
• cannot walk straight
• frequent tumbling and rolling

nervous system
decreased excitatory postsynaptic current amplitude ( J:163029 )
• peak amplitude of climbing fiber EPSCs is further reduced relative to Cacng2tm1Mwa mice
reduced AMPA-mediated synaptic currents ( J:163029 )
• AMPA receptor mediated currents are further reduced relative to Cacng2tm1Mwa mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory