All Phenotypes Dynlt2a1<tm1June> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Dynlt2a1^tm1June
targeted mutation 1, Juergen Neesen
MGI:4820829

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dynlt2a1^tm1June/Dynlt2a1^tm1June	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:4820835

Allelic Composition	Dynlt2a1^tm1June/Dynlt2a1^tm1June
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dynlt2a1^tm1June mutation (0 available); any Dynlt2a1 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal sperm flagellum morphology ( J:162909 )

multiflagellated sperm ( J:162909 )

oligozoospermia ( J:162909 )

• the numbers of spermatocytes and spermatozoa are reduced compared to in wild-type mice

• post-meiotic staged spermatids and spermatozoa are sometimes absent unlike in wild-type mice

abnormal sperm head morphology ( J:162909 )

abnormal male germ cell apoptosis ( J:162909 )

asthenozoospermia ( J:162909 )

• sperm motility and progressive motility is decreased compared to in wild-type cells

• however, axoneme structure is normal

decreased testis weight ( J:162909 )

arrest of spermatogenesis ( J:162909 )

male infertility ( J:162909 )

• some male mice fail to produce offspring

• however, other male mice with reduced sperm motility are fertile

endocrine/exocrine glands

decreased testis weight ( J:162909 )

cellular

abnormal sperm flagellum morphology ( J:162909 )

multiflagellated sperm ( J:162909 )

oligozoospermia ( J:162909 )

• the numbers of spermatocytes and spermatozoa are reduced compared to in wild-type mice

• post-meiotic staged spermatids and spermatozoa are sometimes absent unlike in wild-type mice

abnormal sperm head morphology ( J:162909 )

abnormal male germ cell apoptosis ( J:162909 )

asthenozoospermia ( J:162909 )

• sperm motility and progressive motility is decreased compared to in wild-type cells

• however, axoneme structure is normal

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