Phenotypes associated with this allele

• Allele Symbol: Fzr1^Gt(3003)Tgen
• Allele Name: gene trap 3003, TransGenic
• Allele ID: MGI:4820747
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fzr1^Gt(3003)Tgen/Fzr1^Gt(3003)Tgen	involves: C57BL/6 * CBA	MGI:4830503

Genotype
MGI:4830503

hm1

• Allelic Composition: Fzr1^Gt(3003)Tgen/Fzr1^Gt(3003)Tgen
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:162785 )

• mice begin to die between E10.5 and E12.5

• no mice are alive at E13.5

embryo

absent trophoblast giant cells ( J:162785 )

• no cells with giant nuclei are detected in the placenta unlike in wild-type mice

abnormal placenta labyrinth morphology ( J:162785 )

• at E12.5 and E13.5, abnormal thrombi are present in the labyrinth layers unlike in wild-type mice

abnormal placental labyrinth vasculature morphology ( J:162785 )

cellular

decreased fibroblast cell migration ( J:162785 )

• mouse embryonic fibroblasts exhibit a slight reduction in cellular motility compared with wild-type cells

• mouse embryonic fibroblasts exhibit reduced stress fiber organization compared with wild-type cells

cardiovascular system

abnormal placental labyrinth vasculature morphology ( J:162785 )