About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Btkvila
vila
MGI:4820731
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Btkvila/Btkvila C57BL/6JAnu-Btkvila/AnuApb MGI:4820732


Genotype
MGI:4820732
hm1
Allelic
Composition		 Btkvila/Btkvila
Genetic
Background		 C57BL/6JAnu-Btkvila/AnuApb
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btkvila mutation (2 available); any Btk mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal leukocyte morphology ( J:104190 )
• flow cytometric analysis reveals decreased cell surface expression of CD45 (leukocyte common antigen)
decreased B cell number ( J:104190 )
• detected in peripheral blood by flow cytometry
decreased IgD level ( J:104190 )
• flow cytometric analysis reveals decreased B cell surface IgD expression
increased IgE level ( J:104190 )
• flow cytometric analysis reveals dramatically elevated IgE expression on B cells ("hyper IgE")
increased IgG level ( J:104190 )
• flow cytometric analysis reveals increased IgG expression on B cells

immune system
abnormal leukocyte morphology ( J:104190 )
• flow cytometric analysis reveals decreased cell surface expression of CD45 (leukocyte common antigen)
decreased B cell number ( J:104190 )
• detected in peripheral blood by flow cytometry
decreased IgD level ( J:104190 )
• flow cytometric analysis reveals decreased B cell surface IgD expression
increased IgE level ( J:104190 )
• flow cytometric analysis reveals dramatically elevated IgE expression on B cells ("hyper IgE")
increased IgG level ( J:104190 )
• flow cytometric analysis reveals increased IgG expression on B cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory