Phenotypes associated with this allele

• Allele Symbol: Prkdc^hanky
• Allele Name: hanky
• Allele ID: MGI:4820716
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prkdc^hanky/Prkdc^hanky	either: C57BL/6JAnu or (involves: C57BL/6JAnu * CBA/CaJ)	MGI:4820719

Genotype
MGI:4820719

hm1

• Allelic Composition: Prkdc^hanky/Prkdc^hanky
• Genetic Background: either: C57BL/6JAnu or (involves: C57BL/6JAnu * CBA/CaJ)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

diarrhea ( J:104190 )

cecum inflammation ( J:104190 )

• typhlitis

colitis ( J:104190 )

• marked lymphocytic colitis

hematopoietic system

myeloid hyperplasia ( J:104190 )

• mice that develop interstitial pneumonia also exhibit bone marrow myeloid hyperplasia

increased bone marrow cell number ( J:104190 )

• mice that develop mild interstitial pneumonia also exhibit bone marrow myeloid hyperplasia

increased plasma cell number ( J:104190 )

• plasma cell hyperplasia of the mesenteric lymph nodes

decreased lymphocyte cell number ( J:104190 )

• lymphopenia

immune system

cecum inflammation ( J:104190 )

• typhlitis

colitis ( J:104190 )

• marked lymphocytic colitis

myeloid hyperplasia ( J:104190 )

• mice that develop interstitial pneumonia also exhibit bone marrow myeloid hyperplasia

increased plasma cell number ( J:104190 )

• plasma cell hyperplasia of the mesenteric lymph nodes

decreased lymphocyte cell number ( J:104190 )

• lymphopenia

enlarged mesenteric lymph nodes ( J:104190 )

• reactive mesenteric lymph nodes with plasma cell hyperplasia

lymph node hyperplasia ( J:104190 )

• reactive mesenteric lymph nodes with plasma cell hyperplasia

liver inflammation ( J:104190 )

• mice that develop mild interstitial pneumonia also exhibit foci of mixed centrilobar inflammation in the liver

interstitial pneumonia ( J:104190 )

• some affected mice exhibit mild bronchointerstitial pneumonia, with infiltrates composed predominantly of lymphocytes with lesser numbers of neutrophils

liver/biliary system

liver inflammation ( J:104190 )

• mice that develop mild interstitial pneumonia also exhibit foci of mixed centrilobar inflammation in the liver

respiratory system

interstitial pneumonia ( J:104190 )

• some affected mice exhibit mild bronchointerstitial pneumonia, with infiltrates composed predominantly of lymphocytes with lesser numbers of neutrophils