All Phenotypes Ace2<tm1a(KOMP)Wtsi> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ace2^{tm1a(KOMP)Wtsi}/Ace2^{tm1a(KOMP)Wtsi} Tg(FOXJ1-cre)F26Htzm/0	involves: C57BL/6N * C57BL/6NTac	MGI:6449146
cn2	Ace2^{tm1a(KOMP)Wtsi}/Y Tg(FOXJ1-cre)F26Htzm/0	involves: C57BL/6N * C57BL/6NTac	MGI:6449147

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:282139 )

• mice infected with P. aeruginosa exhibit reduced survival rate

growth/size/body

increased susceptibility to weight loss ( J:282139 )

• mice infected with P. aeruginosa exhibit a greater weight loss than controls

immune system

increased neutrophil cell number ( J:282139 )

• mice infected with P. aeruginosa exhibit increased neutrophil infiltration in the lungs

lung inflammation ( J:282139 )

• mice infected with P. aeruginosa exhibit exaggerated lung inflammation

increased susceptibility to bacterial infection ( J:282139 )

• mice infected with P. aeruginosa exhibit weight loss, enhanced lung permeability, increased neutrophil infiltration into the lungs, reduced bacterial outgrowth in bronchoalveolar lavage fluid, and exaggerated lung inflammation and lung injury compared to controls

increased susceptibility to bacterial infection induced morbidity/mortality ( J:282139 )

• mice infected with P. aeruginosa exhibit reduced survival rate

hematopoietic system

increased neutrophil cell number ( J:282139 )

• mice infected with P. aeruginosa exhibit increased neutrophil infiltration in the lungs

respiratory system

lung inflammation ( J:282139 )

• mice infected with P. aeruginosa exhibit exaggerated lung inflammation

Allelic Composition	Ace2^{tm1a(KOMP)Wtsi}/Y Tg(FOXJ1-cre)F26Htzm/0
Genetic Background	involves: C57BL/6N * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ace2^{tm1a(KOMP)Wtsi} mutation (0 available); any Ace2 mutation (54 available)
Tg(FOXJ1-cre)F26Htzm mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:282139 )

• mice infected with P. aeruginosa exhibit reduced survival rate

growth/size/body

increased susceptibility to weight loss ( J:282139 )

• mice infected with P. aeruginosa exhibit a greater weight loss than controls

immune system

increased neutrophil cell number ( J:282139 )

• mice infected with P. aeruginosa exhibit increased neutrophil infiltration in the lungs

lung inflammation ( J:282139 )

• mice infected with P. aeruginosa exhibit exaggerated lung inflammation

increased susceptibility to bacterial infection ( J:282139 )

increased susceptibility to bacterial infection induced morbidity/mortality ( J:282139 )

• mice infected with P. aeruginosa exhibit reduced survival rate

hematopoietic system

increased neutrophil cell number ( J:282139 )

• mice infected with P. aeruginosa exhibit increased neutrophil infiltration in the lungs

respiratory system

lung inflammation ( J:282139 )

• mice infected with P. aeruginosa exhibit exaggerated lung inflammation

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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