Phenotypes associated with this allele

• Allele Symbol: Cimap3^tm1.1Heli
• Allele Name: targeted mutation 1.1, Heiko Lickert
• Allele ID: MGI:4819764
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Cimap3^tm1.1Heli/Cimap3^+	chimera involves: 129S6/SvEvTac * C57BL/6J	MGI:4819766

Genotype
MGI:4819766

ht1

• Allelic Composition: Cimap3^tm1.1Heli/Cimap3⁺
• Genetic Background: chimera involves: 129S6/SvEvTac * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:162627 )

• embryos generated by tetraploid complementation die around E12.5

reproductive system

male infertility ( J:162627 )

♂ • haploinsufficient male infertility in chimeras

cardiovascular system

double outlet right ventricle ( J:162627 )

• in all embryos generated by tetraploid complementation

embryo

abnormal motile primary cilium physiology ( J:162627 )

• in node and primary limb culture cells the basal body of the cilium fails to detach from the cilium and the cilium is retained during mitosis

abnormal left-right axis patterning ( J:162627 )

• expression analysis indicates disturbed left right patterning in the node and at the early somite stage in embryos generated by tetraploid complementation

abnormal primitive node morphology ( J:162627 )

• slight disruption of the architecture in embryos generated by tetraploid complementation

• expression analysis indicates disturbed left right patterning in the node in embryos generated by tetraploid complementation

abnormal motile primary cilium morphology ( J:162627 )

• in embryos generated by tetraploid complementation about half the cilia in the node show defects that fall into 5 classes: duplication, bifurcation, partial bifurcation, duplication and deformation, and bulging

• in embryos generated by tetraploid complementation, some of the mutant cilia show a nonparallel alignment of the microtubules doublets along the longitudinal axis of the ciliary axoneme and disruption of 9 + 0 arrangement

cellular

abnormal cilium morphology ( J:162627 )

• cells from primary limb cultures display duplicated cilia after cytokinesis

abnormal motile primary cilium morphology ( J:162627 )

• in embryos generated by tetraploid complementation about half the cilia in the node show defects that fall into 5 classes: duplication, bifurcation, partial bifurcation, duplication and deformation, and bulging

• in embryos generated by tetraploid complementation, some of the mutant cilia show a nonparallel alignment of the microtubules doublets along the longitudinal axis of the ciliary axoneme and disruption of 9 + 0 arrangement

abnormal cell physiology ( J:162627 )

• in node and primary limb culture cells the basal body of the cilium fails to detach from the cilium and the cilium is retained during mitosis

abnormal mitosis ( J:162627 )

• cells from primary limb cultures display a high percentage of mitotic defects during cilia disassembly

• overproduction of centrosomes during S phase in cells from primary limb cultures

abnormal motile primary cilium physiology ( J:162627 )

• in node and primary limb culture cells the basal body of the cilium fails to detach from the cilium and the cilium is retained during mitosis