Analysis Tools
immune system
| N |
• mice exhibit normal early antigen-specific B cell response
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Allele Symbol Allele Name Allele ID |
Tg(Lck-cre)#Nik transgene insertion, Nigel Killeen MGI:4819511 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal early antigen-specific B cell response
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• unlike wild-type cells, a portion of peripheral CD4+ T cells expressing CD8
• however, the number of CD4+(CD8+) decreases with age compared with Rr7tm3.1Kio heterozygotes due to cre-mediated removal of the CD2 LCR
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• unlike wild-type cells, a portion of peripheral CD4+ T cells expressing CD8
• however, the number of CD4+(CD8+) decreases with age compared with Rr7tm3.1Kio heterozygotes due to cre-mediated removal of the CD2 LCR
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the frequency of naive T cells in contact with high-endothelial venules is increased compared to in wild-type mice
• in adoptive transfer experiments, T cells exhibit shorter tracks, less displacement from their origin, reduced median speed, lower frequency of cells reaching peak instantaneous velocities, increased median turning angle, decreased average motility coefficient, and greater accumulation in lymph nodes due to impaired lymph node exit compared with wild-type cells
• naive T cells exhibit reduced Transwell chemotaxis in response to CCL21 compared with wild-type cells
• naive T cells exhibit inefficient crawling within a confined environment (8-4 um) compared with wild-type cells
• however, T cell crawling in a large width (12-20 um) lane is normal
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• T cells exhibit a 2-fold greater adhesion to ICAM-1 under flow compared with similarly treated wild-type cells
• naive T cells exhibit inefficient crawling within a confined environment (8-4 um) compared with wild-type cells
• however, T cell crawling in a large width (12-20 um) lane is normal
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• in the periphery (lymph nodes and blood)
• however, thymic populations are normal
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• the frequency of naive T cells in contact with high-endothelial venules is increased compared to in wild-type mice
• T cells exhibit a 2-fold greater adhesion to ICAM-1 under flow compared with similarly treated wild-type cells
• migration of T cells on Transwell membranes is reduced compared with wild-type cells
• in adoptive transfer experiments, T cells exhibit shorter tracks, less displacement from their origin, reduced median speed, lower frequency of cells reaching peak instantaneous velocities, increased median turning angle, decreased average motility coefficient, and greater accumulation in lymph nodes due to impaired lymph node exit compared with wild-type cells
• naive T cells exhibit reduced Transwell chemotaxis in response to CCL21 compared with wild-type cells
• naive T cells exhibit inefficient crawling within a confined environment compared with wild-type cells
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• despite a reduction in number, the percentage of CD8+ T cells in the lymph nodes tends to increase compared to in wild-type mice
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• despite a reduction in number, the percentage of CD8+ T cells in the lymph nodes tends to increase compared to in wild-type mice
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• the frequency of naive T cells in contact with high-endothelial venules is increased compared to in wild-type mice
• in adoptive transfer experiments, T cells exhibit shorter tracks, less displacement from their origin, reduced median speed, lower frequency of cells reaching peak instantaneous velocities, increased median turning angle, decreased average motility coefficient, and greater accumulation in lymph nodes due to impaired lymph node exit compared with wild-type cells
• naive T cells exhibit reduced Transwell chemotaxis in response to CCL21 compared with wild-type cells
• naive T cells exhibit inefficient crawling within a confined environment (8-4 um) compared with wild-type cells
• however, T cell crawling in a large width (12-20 um) lane is normal
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|
• T cells exhibit a 2-fold greater adhesion to ICAM-1 under flow compared with similarly treated wild-type cells
• naive T cells exhibit inefficient crawling within a confined environment (8-4 um) compared with wild-type cells
• however, T cell crawling in a large width (12-20 um) lane is normal
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• in the periphery (lymph nodes and blood)
• however, thymic populations are normal
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• the frequency of naive T cells in contact with high-endothelial venules is increased compared to in wild-type mice
• T cells exhibit a 2-fold greater adhesion to ICAM-1 under flow compared with similarly treated wild-type cells
• migration of T cells on Transwell membranes is reduced compared with wild-type cells
• in adoptive transfer experiments, T cells exhibit shorter tracks, less displacement from their origin, reduced median speed, lower frequency of cells reaching peak instantaneous velocities, increased median turning angle, decreased average motility coefficient, and greater accumulation in lymph nodes due to impaired lymph node exit compared with wild-type cells
• naive T cells exhibit reduced Transwell chemotaxis in response to CCL21 compared with wild-type cells
• naive T cells exhibit inefficient crawling within a confined environment compared with wild-type cells
|
|
• despite a reduction in number, the percentage of CD8+ T cells in the lymph nodes tends to increase compared to in wild-type mice
|
|
• the frequency of naive T cells in contact with high-endothelial venules is increased compared to in wild-type mice
• in adoptive transfer experiments, T cells exhibit shorter tracks, less displacement from their origin, reduced median speed, lower frequency of cells reaching peak instantaneous velocities, increased median turning angle, decreased average motility coefficient, and greater accumulation in lymph nodes due to impaired lymph node exit compared with wild-type cells
• naive T cells exhibit reduced Transwell chemotaxis in response to CCL21 compared with wild-type cells
• naive T cells exhibit inefficient crawling within a confined environment (8-4 um) compared with wild-type cells
• however, T cell crawling in a large width (12-20 um) lane is normal
|
|
• T cells exhibit a 2-fold greater adhesion to ICAM-1 under flow compared with similarly treated wild-type cells
• naive T cells exhibit inefficient crawling within a confined environment (8-4 um) compared with wild-type cells
• however, T cell crawling in a large width (12-20 um) lane is normal
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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