Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd40lgm1Btlr mutation
(1 available);
any
Cd40lg mutation
(14 available)
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immune system
N |
• normal T cell independent IgM responses and serum IgA levels
• normal frequencies and surface phenotypes of T and B cells in peripheral blood
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• failure of the T cell dependent IgG response to the model antigen beta-galactosidase encoded by recombinant Semliki Forest Virus (rSFV)
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hematopoietic system
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• failure of the T cell dependent IgG response to the model antigen beta-galactosidase encoded by recombinant Semliki Forest Virus (rSFV)
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd40lgm1Btlr mutation
(1 available);
any
Cd40lg mutation
(14 available)
|
|
|
immune system
N |
• mice exhibit normal peripheral blood lymphocytes
• mice exhibit a normal response to NP-Ficoll
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• mice exhibit reduced class-switch antibody response in response to recombinant Semliki Forest virus (SFV) encoded antigen compared with control mice
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• response in response to recombinant Semliki Forest virus (SFV) encoded antigen
|
hematopoietic system
|
• mice exhibit reduced class-switch antibody response in response to recombinant Semliki Forest virus (SFV) encoded antigen compared with control mice
|
|
• response in response to recombinant Semliki Forest virus (SFV) encoded antigen
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Allelic Composition |
Cd40lgm1Btlr/Y
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Genetic Background |
involves: C57BL/6J |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd40lgm1Btlr mutation
(1 available);
any
Cd40lg mutation
(14 available)
|
|
|
immune system
N |
• mice exhibit normal peripheral blood lymphocytes
• mice exhibit a normal response to NP-Ficoll
|
|
• mice exhibit reduced class-switch antibody response in response to recombinant Semliki Forest virus (SFV) encoded antigen compared with control mice
|
|
• response in response to recombinant Semliki Forest virus (SFV) encoded antigen
|
hematopoietic system
|
• mice exhibit reduced class-switch antibody response in response to recombinant Semliki Forest virus (SFV) encoded antigen compared with control mice
|
|
• response in response to recombinant Semliki Forest virus (SFV) encoded antigen
|