Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(DUX4)Sqh mutation
(1 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Tg(ACTA1-rtTA,tetO-cre)102Monk mutation
(1 available)
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mortality/aging
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• less than 3% of the expected 25% of mutant pups are born and those pups then die immediately
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl6tm1Gdba mutation
(0 available);
any
Bcl6 mutation
(55 available)
Tg(ACTA1-rtTA,tetO-cre)102Monk mutation
(1 available)
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adipose tissue
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• dox-treated mice develop increased white adipose tissue in all depots, including the inguinal, interscapular, perigonadal, perinephric, and interscarpular adipose tissues but not brown adipose tissue
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• mice treated with doxycycline (dox) for 7 days at 8 weeks of age exhibit a higher fat mass within 4 weeks after dox treatment
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• adipocyte size is increased in all white adipose tissue depots of dox-treated mice
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growth/size/body
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• mice treated with doxycycline (dox) for 7 days at 8 weeks of age exhibit a higher fat mass within 4 weeks after dox treatment
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etfdhtm1c(EUCOMM)Hmgu mutation
(0 available);
any
Etfdh mutation
(28 available)
Tg(ACTA1-rtTA,tetO-cre)102Monk mutation
(1 available)
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behavior/neurological
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• 6-month-old doxycycline-treated mice show decreased performance on the rotarod test and the two-limb hanging test in response to fasting, but not in the fed state
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cellular
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• some skeletal muscle mitochondria from doxycycline-treated mice appear swollen, empty and with cristae disorganization
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• isolated mitochondria from skeletal muscle shows reduced oxidative phosphorylation complex III (CIII) activity
• cytochrome c production in isolated mitochondria is reduced to 54% of wild-type
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growth/size/body
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• doxycycline-treated mice exhibit reduced body weight by 5-6 months of age
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• 5-month-old doxycycline-treated mice show a poorer response to fasting, showing greater weight loss after fasting than controls
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muscle
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• some skeletal muscle mitochondria from doxycycline-treated mice appear swollen, empty and with cristae disorganization
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• mice show increased skeletal muscle de novo lipid synthesis in close contact with dysfunctional mitochondria
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• skeletal muscle from doxycycline-treated mice shows fiber shrinkage, sarcomere disorganization and debris, indicating myopathy
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Analysis Tools
