Phenotypes associated with this allele

• Allele Symbol: Hoxb8^{tm3.1(IRES-rtTA2*M2)Mrc}
• Allele Name: targeted mutation 3.1, Mario R Capecchi
• Allele ID: MGI:4818439
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Hoxb8^tm3.1(IRES-rtTA2*M2)Mrc/Hoxb8^tm3.1(IRES-rtTA2*M2)Mrc Tg(Tek-cre)1Arnd/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * DBA/2	MGI:4818891
cn2	Hoxb8^tm3.1(IRES-rtTA2*M2)Mrc/Hoxb8^tm3.1(IRES-rtTA2*M2)Mrc Hoxc8^tm2.1(cre)Mrc/?	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:4818894

Genotype
MGI:4818891

cn1

• Allelic Composition: Hoxb8^{tm3.1(IRES-rtTA2*M2)Mrc}/Hoxb8^{tm3.1(IRES-rtTA2*M2)Mrc}; Tg(Tek-cre)1Arnd/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:162102 )

N • heat insensitivity is not observed in mutants

increased grooming behavior ( J:162102 )

• animals show significantly lengthened grooming times compared to wild-type controls with deletion of Hoxb8 in hematopoietic system; behavior is comparable to complete Hoxb8 null animals

nervous system

nervous system phenotype ( J:162102 )

N • morphology of dorsal spinal cord laminae I and II appears normal, based on labeling for interneurons

integument

focal hair loss ( J:162102 )

• hairless patches develop in most animals due to excessive grooming

Genotype
MGI:4818894

cn2

• Allelic Composition: Hoxb8^{tm3.1(IRES-rtTA2*M2)Mrc}/Hoxb8^{tm3.1(IRES-rtTA2*M2)Mrc}; Hoxc8^{tm2.1(cre)Mrc}/?
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

behavior/neurological

behavior/neurological phenotype ( J:162102 )

N • excessive grooming behavior is not observed in mutants

increased thermal nociceptive threshold ( J:162102 )

• mutants have significantly greater latency time in response to heat

nervous system

abnormal spinal cord dorsal horn morphology ( J:162102 )

• reduction in numbers interneurons in laminae I and II are detected, based on labeling for calbindin and calretinin

• in adult animals, significant decrease in neuronal cell body numbers is detected relative to wild-type controls