All Phenotypes Fgf22<tm1Dgen> MGI Mouse

Phenotypes associated with this allele

Allelic Composition	Fgf22^tm1Dgen/Fgf22^tm1Dgen
Genetic Background	B6.Cg-Fgf22^tm1Dgen

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf22^tm1Dgen mutation (0 available); any Fgf22 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

• pentylenetetrazol-treated mice fail to exhibit seizures at doses that elicit seizures in wild-type mice

nervous system

• pentylenetetrazol-treated mice fail to exhibit seizures at doses that elicit seizures in wild-type mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

• at asymmetric synapses, synaptic vesicles are more diffusely distributed and smaller than in wild-type mice

abnormal synaptic vesicle number ( J:161954 )

• fewer vesicles are docked at asymmetric synapses compared to in wild-type mice

• however, the number of docked vesicles at symmetric synapses is normal

• at P14, vesicle clustering in glutamatergic synapses is decreased in the CA3 compared to in wild-type mice

• CA3 pyramidal neurons cultured for 14 days have fewer glutamatergic vesicles associated with dendrites compared to in cultured wild-type neurons

• however, vesicle clustering in GABAergic synapses is normal

• the frequency of miniature excitatory postsynaptic currents (mEPSCs) is decreased compared to in wild-type hippocampal cultures

• however, the amplitude of mEPSCs is normal

increased synaptic depression ( J:161954 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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